Results 221 to 230 of about 10,817 (281)
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Monoclonal antibodies against soman: characterization of soman stereoisomers
Immunology Letters, 1992Hybridomas were produced which expressed monoclonal anti-soman antibodies as determined by microtiter enzyme-linked-antibody immunoassay (EIA). Each of these antibodies was titrated using a competitive inhibition enzyme immunoassay (CIEIA) with a variety of test ligands. The ligands used included soman (a racemic mixture), sarin, tabun, and each of the
David E Lenz +2 more
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Treatment of Poisoning by Soman
Toxicological Sciences, 1985The efficacies of a number of drug treatment combinations in protecting guinea pigs against the lethal and incapacitating effects of soman (and sarin) have been determined. Incapacitation was studied using a swimming test which is a measure of gross motor performance.
L, Leadbeater, R H, Inns, J M, Rylands
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Characterization of soman-binding antibodies raised against soman analogs
Molecular Immunology, 1992The production of antibodies against the highly toxic organophosphorus compound soman (GD) has been undertaken. Monoclonal antibodies were raised against two structural analogs of soman which served as haptens for immunization. In these soman analogs the chemically active P-F bond of the soman molecule was substituted by a P-OH group (which is ionized ...
M, Glikson +5 more
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A method for generating toxic vapors of soman: Toxicity of soman by inhalation in rats
Toxicology and Applied Pharmacology, 1985A method for administration of highly toxic chemicals by inhalation was developed. The model has three features of special interest: (1) a diffusion cell for producing a constant gas concentration, if necessary for several hours and days, (2) a small rapidly equilibrated inhalation chamber (1100 ml), and (3) complete isolation of the toxic chemicals ...
P, Aas +3 more
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A pharmacodynamic model for soman in the rat
Toxicology Letters, 1988A pharmacodynamic model for inhibition of acetylcholinesterase (AChE) by soman was developed to describe the intertissue differences in AChE inhibition, the dose response of AChE to inhibition by soman, and the effect of differences in xenobiotic metabolism on soman toxicity.
D M, Maxwell, C P, Vlahacos, D E, Lenz
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Pathophysiology of Soman intoxication in primates
Toxicology and Applied Pharmacology, 1986Adult baboons were monitored during intravenous infusion of Soman (1,2,2-trimethylpropyl ester, phosphonofluoridate). Three groups of animals were studied. Two groups were anesthetized with sodium pentobarbital (initial dose, 20 mg/kg), instrumented for measurement of systemic blood pressure (BP), pulmonary artery pressure, cardiac output (CO), ECG ...
A, Anzueto +6 more
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Distribution of 3H-soman in mice
Archives of Toxicology, 19853H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed.
T, Kadar +7 more
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Anticonvulsants for soman-induced seizure activity
Journal of Biomedical Science, 1999 This report describes studies of anticonvulsants for the organophosphorus (OP) nerve agent soman: a basic research effort to understand how different pharmacological classes of compounds influence the expression of seizure produced by soman in rats, and a drug screening effort to determine whether clinically useful antiepileptics can modulate soman ...
John McDonough +2 more
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Neurochemical Mechanisms in Soman-induced Seizures
Journal of Applied Toxicology, 1997This study examined brain regional neurotransmitter level changes as a function of seizure duration following soman intoxication. Rats, implanted with cortical electrodes and pretreated with HI-6, received a convulsant dose of soman. At selected times after seizure onset the EEG recording electrodes were removed and the animal was killed.
T M, Shih, J H, McDonough
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Absolute configuration of somane
Russian Chemical Bulletin, 1993PhCH2Ct K2C% Some parameters of the synthesized compounds are given below: b.p./~ (t7, Torr), n/) 20, m.p./~ (for hydrochloride): la, 53--54 (1), 1.4893, 177.5--178.5 (el ref. 1); lb, 85--86 (1), 1.5251, 165--166; 2a, 52--53 (1), 1.4854, 225--226; 2b, 98 (1.5), 1.5242, 162--162.5; 5, 62 (1), 1.4531, 225--226; 6, --, --, 132.5--143; 7, 120 (1), 1.5132,--
K. F. Koehler +4 more
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