Results 221 to 230 of about 30,847 (287)

Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension.

JAMA Cardiol
Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M.   +33 more
europepmc   +1 more source

Anticonvulsants for soman-induced seizure activity

Journal of Biomedical Science, 1999
This report describes studies of anticonvulsants for the organophosphorus (OP) nerve agent soman: a basic research effort to understand how different pharmacological classes of compounds influence the expression of seizure produced by soman in rats, and a drug screening effort to determine whether clinically useful antiepileptics can modulate soman ...
Tsung-Ming Shih
exaly   +3 more sources

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Monoclonal antibodies against soman: characterization of soman stereoisomers

Immunology Letters, 1992
Hybridomas were produced which expressed monoclonal anti-soman antibodies as determined by microtiter enzyme-linked-antibody immunoassay (EIA). Each of these antibodies was titrated using a competitive inhibition enzyme immunoassay (CIEIA) with a variety of test ligands. The ligands used included soman (a racemic mixture), sarin, tabun, and each of the
D E, Lenz, J J, Yourick, J S, Dawson, J, Scott   +3 more
openaire   +2 more sources

Characterization of soman-binding antibodies raised against soman analogs

Molecular Immunology, 1992
The production of antibodies against the highly toxic organophosphorus compound soman (GD) has been undertaken. Monoclonal antibodies were raised against two structural analogs of soman which served as haptens for immunization. In these soman analogs the chemically active P-F bond of the soman molecule was substituted by a P-OH group (which is ionized ...
M, Glikson, R, Arad-Yellin, M, Ghozi, L, Raveh, B S, Green, Z, Eshhar   +5 more
openaire   +2 more sources

Pharmacological modulation of soman-induced seizures

Neuroscience and Biobehavioral Reviews, 1993
Anticholinergics, benzodiazepines and N-methyl-D-aspartate (NMDA) antagonists have been shown to modulate the expression of nerve agent-induced seizures. This study examined whether the anticonvulsant actions of these drugs varied depending on the duration of prior seizure activity. Rats implanted with electrodes to record electroencephalographic (EEG)
Tsung-Ming Shih
exaly   +3 more sources

Treatment of Poisoning by Soman

Toxicological Sciences, 1985
The efficacies of a number of drug treatment combinations in protecting guinea pigs against the lethal and incapacitating effects of soman (and sarin) have been determined. Incapacitation was studied using a swimming test which is a measure of gross motor performance.
L, Leadbeater, R H, Inns, J M, Rylands
openaire   +2 more sources

Naked DNA prevents soman intoxication

Biochemical and Biophysical Research Communications, 2005
Paraoxonase (Q isoenzyme, PON1) can effectively hydrolyze chlorpyrifos-oxon (CPO), soman, sarin, and other organophosphates. Previous studies had indicated that the levels of serum PON1 in gene therapy with adenoviral vector could decrease the toxicity of CPO.
Ai Ling, Fu, Yu Xia, Wang, Man Ji, Sun
openaire   +2 more sources