Results 221 to 230 of about 9,449 (276)

Distribution of 3H-soman in mice

Archives of Toxicology, 1985
3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed.
T, Kadar, L, Raveh, G, Cohen, N, Oz, I, Baranes, A, Balan, Y, Ashani, S, Shapira   +7 more
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Pathophysiology of Soman intoxication in primates

Toxicology and Applied Pharmacology, 1986
Adult baboons were monitored during intravenous infusion of Soman (1,2,2-trimethylpropyl ester, phosphonofluoridate). Three groups of animals were studied. Two groups were anesthetized with sodium pentobarbital (initial dose, 20 mg/kg), instrumented for measurement of systemic blood pressure (BP), pulmonary artery pressure, cardiac output (CO), ECG ...
A, Anzueto, G G, Berdine, G T, Moore, C, Gleiser, D, Johnson, C D, White, W G, Johanson   +6 more
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Toxicokinetics of the four stereoisomers of the nerve agent soman in atropinized rats—Influence of a soman simulator

Toxicology and Applied Pharmacology, 1987
The toxicokinetics of the four stereoisomers of C(+/-)P(+/-)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 micrograms/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum ...
Benschop, H.P., Bijleveld, E.C., Jong, L.P.A. de, Wiel, H.J. van der, Helden, H.P.M. van   +4 more
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Neurochemical Mechanisms in Soman-induced Seizures

Journal of Applied Toxicology, 1997
This study examined brain regional neurotransmitter level changes as a function of seizure duration following soman intoxication. Rats, implanted with cortical electrodes and pretreated with HI-6, received a convulsant dose of soman. At selected times after seizure onset the EEG recording electrodes were removed and the animal was killed.
T M, Shih, J H, McDonough
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Absolute configuration of somane

Russian Chemical Bulletin, 1993
PhCH2Ct K2C% Some parameters of the synthesized compounds are given below: b.p./~ (t7, Torr), n/) 20, m.p./~ (for hydrochloride): la, 53--54 (1), 1.4893, 177.5--178.5 (el ref. 1); lb, 85--86 (1), 1.5251, 165--166; 2a, 52--53 (1), 1.4854, 225--226; 2b, 98 (1.5), 1.5242, 162--162.5; 5, 62 (1), 1.4531, 225--226; 6, --, --, 132.5--143; 7, 120 (1), 1.5132,--
K. F. Koehler, H. Zaddach, A. D. Kuntsevich, I. I. Chervin, R. G. Kostyanovsky   +4 more
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Binding of soman antidotes to acetylcholine receptors

Biochemical Pharmacology, 1987
It has been reported that several bis-quaternary compounds not necessarily having an oxime function can be used to treat soman poisoning in mice. The mechanism for this protection is not clear, but it has been proposed that such compounds may act by blocking muscarinic or nicotinic acetylcholine receptors.
C, Broomfield, I J, Dembure, J, Cuculis
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Soman-induced convulsions: The neuropathology revisited

Toxicology, 2005
The organophosphorus compound soman, an irreversible inhibitor of cholinesterases, produces seizure activity and related brain damage. Studies using various biochemical markers of programmed cell death (PCD) suggested that soman-induced cell damage in the brain was apoptotic rather than necrotic.
Valérie, Baille, Peter G H, Clarke, Guy, Brochier, Frédéric, Dorandeu, Jean-Marc, Verna, Elise, Four, Guy, Lallement, Pierre, Carpentier   +7 more
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Toxogonin in Sarin, Soman and Tabun poisoning

Biochemical Pharmacology, 1965
The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
E, HEILBRONN, B, TOLAGEN
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Naked DNA prevents soman intoxication

Biochemical and Biophysical Research Communications, 2005
Paraoxonase (Q isoenzyme, PON1) can effectively hydrolyze chlorpyrifos-oxon (CPO), soman, sarin, and other organophosphates. Previous studies had indicated that the levels of serum PON1 in gene therapy with adenoviral vector could decrease the toxicity of CPO.
Ai Ling, Fu, Yu Xia, Wang, Man Ji, Sun
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Effects of soman on neuroendocrine and immune function

Neurotoxicology and Teratology, 1991
We have previously reported that plasma growth hormone (GH) and prolactin levels were markedly decreased in rats two weeks following a single dose (100 micrograms/kg, SC) of soman. We have now conducted additional experiments to attempt to determine whether neuroendocrine responses to physiological or pharmacological challenge are altered in rat ...
G J, Kant, T M, Shih, E W, Bernton, H G, Fein, R C, Smallridge, E H, Mougey   +5 more
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