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Developmental toxicity of soman in rats and rabbits
Teratology, 1990AbstractSoman (GD; phosphonofluoridic acid, methyl‐,1,2,2‐trimethylpropyl ester) is an organophosphate compound with potent anticholinesterase activity. To determine developmental toxicity, soman was administered orally to CD rats on days 6 through 15 of gestation at dose levels of 0, 37.5, 75, 150, or 165 μg/kg/day and to New Zealand White (NZW ...
H K, Bates +3 more
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Cardiomyopathy in Soman and Sarin intoxicated rats
Toxicology Letters, 1987Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication ...
A W, Singer +3 more
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Inactivation of sarin and soman by cyclodextrins in vitro
Experientia, 1987Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more
B, Désiré, S, Saint-André
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Pharmacological modulation of soman-induced seizures
Neuroscience & Biobehavioral Reviews, 1993Anticholinergics, benzodiazepines and N-methyl-D-aspartate (NMDA) antagonists have been shown to modulate the expression of nerve agent-induced seizures. This study examined whether the anticonvulsant actions of these drugs varied depending on the duration of prior seizure activity. Rats implanted with electrodes to record electroencephalographic (EEG)
J H, McDonough, T M, Shih
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Toxicology and Applied Pharmacology, 1998
The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were studied in anesthetized, atropinized guinea pigs for nose-only exposure to soman vapor. During exposure the respiratory minute volume (RMV) and respiratory frequency (RF) were monitored.
Langenberg, J.P. +7 more
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The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were studied in anesthetized, atropinized guinea pigs for nose-only exposure to soman vapor. During exposure the respiratory minute volume (RMV) and respiratory frequency (RF) were monitored.
Langenberg, J.P. +7 more
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The Treatment of Soman Poisoning and its Perspectives
Toxicological Sciences, 1981Soman is a highly toxic organophosphorus chemical warfare nerve agent which is characterized by (1) extremely rapid ageing of the phosphonylated enzyme, (2) poor reactivation of inhibited AChE due to a steric factor, (3) pronounced CNS effects, and (4) tentative direct toxic biochemical effects.
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Visual detection of soman metabolites in zebrafish
Analytical MethodsSoman, an organophosphate compound, is readily converted into pinacolyl methylphosphonic acid in the environment.
Xing-Xing Zong +5 more
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Soman Intoxication and the Blood-Brain Barrier
Toxicological Sciences, 1985Brain capillaries (microvessels) were isolated from rabbit brain. Morphological characterization revealed relatively pure fractions of microvessels consisting of the capillary endothelium, the basal membrane, and the pericyte. These fractions of brain capillaries show acetylcholinesterase (AChE) and monoamine oxidase (MAO) activity, but lack catechol-O-
A, Sellström, G, Algers, B, Karlsson
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Neurobehavioral toxicology and teratology, 1986
When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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Search for a therapy against soman-intoxication
Neuroscience & Biobehavioral Reviews, 1994This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. In particular soman, because this is one of the nerve agents that consistently appears
O L, Wolthuis +4 more
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