Results 231 to 240 of about 10,817 (281)

Binding of soman antidotes to acetylcholine receptors

Biochemical Pharmacology, 1987
It has been reported that several bis-quaternary compounds not necessarily having an oxime function can be used to treat soman poisoning in mice. The mechanism for this protection is not clear, but it has been proposed that such compounds may act by blocking muscarinic or nicotinic acetylcholine receptors.
C, Broomfield, I J, Dembure, J, Cuculis
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Soman-induced convulsions: The neuropathology revisited

Toxicology, 2005
The organophosphorus compound soman, an irreversible inhibitor of cholinesterases, produces seizure activity and related brain damage. Studies using various biochemical markers of programmed cell death (PCD) suggested that soman-induced cell damage in the brain was apoptotic rather than necrotic.
Valérie, Baille, Peter G H, Clarke, Guy, Brochier, Frédéric, Dorandeu, Jean-Marc, Verna, Elise, Four, Guy, Lallement, Pierre, Carpentier   +7 more
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Naked DNA prevents soman intoxication

Biochemical and Biophysical Research Communications, 2005
Paraoxonase (Q isoenzyme, PON1) can effectively hydrolyze chlorpyrifos-oxon (CPO), soman, sarin, and other organophosphates. Previous studies had indicated that the levels of serum PON1 in gene therapy with adenoviral vector could decrease the toxicity of CPO.
Ai Ling, Fu, Yu Xia, Wang, Man Ji, Sun
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Developmental toxicity of soman in rats and rabbits

Teratology, 1990
AbstractSoman (GD; phosphonofluoridic acid, methyl‐,1,2,2‐trimethylpropyl ester) is an organophosphate compound with potent anticholinesterase activity. To determine developmental toxicity, soman was administered orally to CD rats on days 6 through 15 of gestation at dose levels of 0, 37.5, 75, 150, or 165 μg/kg/day and to New Zealand White (NZW ...
H K, Bates, J B, LaBorde, J C, Dacre, J F, Young   +3 more
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Cardiomyopathy in Soman and Sarin intoxicated rats

Toxicology Letters, 1987
Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication ...
A W, Singer, N K, Jaax, J S, Graham, C G, McLeod   +3 more
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Successful oxime therapy one hour after soman intoxication in the rat

European Journal of Pharmacology, 1978
The bisquarternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e.
O L Wolthuis, Otto L Wolthuis
exaly   +1 more source

Pharmacological modulation of soman-induced seizures

Neuroscience & Biobehavioral Reviews, 1993
Anticholinergics, benzodiazepines and N-methyl-D-aspartate (NMDA) antagonists have been shown to modulate the expression of nerve agent-induced seizures. This study examined whether the anticonvulsant actions of these drugs varied depending on the duration of prior seizure activity. Rats implanted with electrodes to record electroencephalographic (EEG)
J H, McDonough, T M, Shih
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Search for a therapy against soman-intoxication

Neuroscience & Biobehavioral Reviews, 1994
This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. In particular soman, because this is one of the nerve agents that consistently appears
O L, Wolthuis, H P, van Helden, B P, Melchers, R W, Busker, D M, de Groot   +4 more
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The Treatment of Soman Poisoning and its Perspectives

Toxicological Sciences, 1981
Soman is a highly toxic organophosphorus chemical warfare nerve agent which is characterized by (1) extremely rapid ageing of the phosphonylated enzyme, (2) poor reactivation of inhibited AChE due to a steric factor, (3) pronounced CNS effects, and (4) tentative direct toxic biochemical effects.
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Effects of soman on neuroendocrine and immune function

Neurotoxicology and Teratology, 1991
We have previously reported that plasma growth hormone (GH) and prolactin levels were markedly decreased in rats two weeks following a single dose (100 micrograms/kg, SC) of soman. We have now conducted additional experiments to attempt to determine whether neuroendocrine responses to physiological or pharmacological challenge are altered in rat ...
G J, Kant, T M, Shih, E W, Bernton, H G, Fein, R C, Smallridge, E H, Mougey   +5 more
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