Results 241 to 250 of about 10,817 (281)
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Soman Intoxication and the Blood-Brain Barrier
Toxicological Sciences, 1985Brain capillaries (microvessels) were isolated from rabbit brain. Morphological characterization revealed relatively pure fractions of microvessels consisting of the capillary endothelium, the basal membrane, and the pericyte. These fractions of brain capillaries show acetylcholinesterase (AChE) and monoamine oxidase (MAO) activity, but lack catechol-O-
A, Sellström, G, Algers, B, Karlsson
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Toxogonin in Sarin, Soman and Tabun poisoning
Biochemical Pharmacology, 1965The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
E, HEILBRONN, B, TOLAGEN
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Neurobehavioral toxicology and teratology, 1986
When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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Toxicology and Applied Pharmacology, 2004
The combined effects of physostigmine and procyclidine (antagonizing muscarinic, nicotinic, and NMDA receptors) were tested against various doses of soman. Physostigmine (0.1 mg/kg) in combination with procyclidine doses of 1, 3, or 6 mg/kg effectively prevented the development of convulsions and hippocampally monitored seizures when the doses of soman
Trond, Myhrer +3 more
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The combined effects of physostigmine and procyclidine (antagonizing muscarinic, nicotinic, and NMDA receptors) were tested against various doses of soman. Physostigmine (0.1 mg/kg) in combination with procyclidine doses of 1, 3, or 6 mg/kg effectively prevented the development of convulsions and hippocampally monitored seizures when the doses of soman
Trond, Myhrer +3 more
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Acute Inhalation Toxicity of Soman and Sarin in Baboons
Toxicological Sciences, 1990Adult baboons (Papio sp.; 8-12 kg) were anesthesized with sodium pentobarbital (20 mg/kg iv). The animals were instrumented for measurement of mean blood pressure (MBP), pulmonary artery pressure (PAP), ECG, arterial and mixed venous blood gases, lung volumes, lung pressures, and efferent phrenic nerve activity.
A, Anzueto +6 more
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Acta pharmacologica Sinica, 2003
To investigate the effect of nimodipine on the elimination of soman in rabbit blood and distribution of [3H]soman in mice.Chirasil capillary gas chromatographic analysis method with large volume injections was used to determine the concentration of C(+/-)P(-)soman in rabbit blood.
Jin-Tong, Li +5 more
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To investigate the effect of nimodipine on the elimination of soman in rabbit blood and distribution of [3H]soman in mice.Chirasil capillary gas chromatographic analysis method with large volume injections was used to determine the concentration of C(+/-)P(-)soman in rabbit blood.
Jin-Tong, Li +5 more
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Inactivation of sarin and soman by cyclodextrins in vitro
Experientia, 1987Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more
B, Désiré, S, Saint-André
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Visual detection of soman metabolites in zebrafish
Analytical MethodsSoman, an organophosphate compound, is readily converted into pinacolyl methylphosphonic acid in the environment.
Xing-Xing Zong +5 more
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Problems in the therapy of soman poisoning
Fundamental and Applied Toxicology, 1981O L, Wolthuis, F, Berends, E, Meeter
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