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Monoclonal antibodies against soman: characterization of soman stereoisomers
Immunology Letters, 1992Hybridomas were produced which expressed monoclonal anti-soman antibodies as determined by microtiter enzyme-linked-antibody immunoassay (EIA). Each of these antibodies was titrated using a competitive inhibition enzyme immunoassay (CIEIA) with a variety of test ligands. The ligands used included soman (a racemic mixture), sarin, tabun, and each of the
J.J. Yourick +3 more
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Treatment of Poisoning by Soman
Toxicological Sciences, 1985The efficacies of a number of drug treatment combinations in protecting guinea pigs against the lethal and incapacitating effects of soman (and sarin) have been determined. Incapacitation was studied using a swimming test which is a measure of gross motor performance.
L. Leadbeater, J. M. Rylands, R. H. Inns
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Characterization of soman-binding antibodies raised against soman analogs
Molecular Immunology, 1992The production of antibodies against the highly toxic organophosphorus compound soman (GD) has been undertaken. Monoclonal antibodies were raised against two structural analogs of soman which served as haptens for immunization. In these soman analogs the chemically active P-F bond of the soman molecule was substituted by a P-OH group (which is ionized ...
Rina Arad-Yellin +5 more
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A pharmacodynamic model for soman in the rat
Toxicology Letters, 1988A pharmacodynamic model for inhibition of acetylcholinesterase (AChE) by soman was developed to describe the intertissue differences in AChE inhibition, the dose response of AChE to inhibition by soman, and the effect of differences in xenobiotic metabolism on soman toxicity.
Donald M. Maxwell +2 more
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