Results 81 to 90 of about 3,823 (149)

Benchmarking long-read assembly tools and preprocessing strategies for bacterial genomes: A case study on <i>E. coli</i> DH5α. [PDF]

Biotechnol Rep (Amst)
Kumar MS, Krishna MB, Soman KP, Stanley J, Pourmand N, Suravajhala P, Babu TGS.   +6 more
europepmc   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Enhanced Antitumor Activity of Korean Black Soybean Cultivar 'Soman' by Targeting STAT-Mediated Aerobic Glycolysis. [PDF]

Antioxidants (Basel)
Park SH, Seo JH, Kim MY, Yun HJ, Kang BK, Kim JH, Heo SV, Lee YH, Park HR, Choi MS, Lee JH.   +10 more
europepmc   +1 more source

Multifunctional Carbon Dots for Electrochemical Capacitors Reviewed: Their Opportunities and Challenges

Advanced Science, EarlyView.
Carbon dots (CDs) with unique natures of small size, high specific surface area, and tunable surface functional groups significantly enhance the specific capacitance and cycling stability of electrochemical capacitors (ECs). This review systematically discusses critical challenges and opportunities associated with multifunctional CDs in ECs, aiming to ...
Naiyun Liu, Jingwen Yu, Yaxi Li, Yunliang Liu, Sobia Jabeen, Yuanyuan Cheng, Lei Zhou, Dmitri L. Danilov, Peter H. L. Notten, Haitao Li   +9 more
wiley   +1 more source

Prevalence of maxillary midline diastema and its societal perception in patients at Remera health center, Rwanda. [PDF]

Bioinformation
Soman D, Elangovan R, C Maganti D, Rachel K, Cedric M, John Peter I.   +5 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy. [PDF]

PLoS One
Turner SR, Timperley CM, Bird M, Green AC, Price ME, Rice H, Chad JE, Tattersall JEH.   +7 more
europepmc   +1 more source

Material‐to‐Application Integration: Rapid Fabrication of Field‐Deployable Hydrogel‐SiO2 DNA Separator for Low‐Resource Point‐of‐Care Diagnostics

Advanced Science, EarlyView.
A rapidly fabricated hydrogel‐SiO2 composite enables ultralow‐cost, equipment‐minimized DNA extraction, outperforming commercial kits. Hierarchical microstructures enhance hydrophobic/salt‐bridge‐driven adsorption. Integrated with visual LAMP, this field‐deployable system detects Vibrio parahaemolyticus at 10 CFU mL−1 in <40 min, offering ...
Peipei Li, Xinrong Li, Haojie Wu, Dongmei Yue, Yubo Shang, Shan Gao, Bai Wang, Xiaobin Jiang, Jingwei Jiang, Zunchun Zhou   +9 more
wiley   +1 more source

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats. [PDF]

CNS Neurosci Ther
Andrew PM, MacMahon JA, Liu X, Saito NH, Berger KE, Morgan JE, Dhir A, Harvey DJ, McCarren HS, Rogawski MA, Lein PJ.   +10 more
europepmc   +1 more source

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects against In Vivo Infection via the Induction of Broad‐Spectrum PRRSV Neutralization

Advanced Science, EarlyView.
This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A. Hiscox, James P. Stewart, Yani Sun, Qin Zhao   +12 more
wiley   +1 more source