Results 21 to 30 of about 938,133 (296)
TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis
Genomics, Proteomics & Bioinformatics, 2018 Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune checkpoint blockade therapy and as potential targets for cancer immunotherapy.
Jingcheng Wu +6 more
doaj +1 more source
Indian Journal of Animal Sciences, 2020 Paramphistomosis is the emerging fluke infection in young ruminants which results in high morbidity and mortality in tropics and sub-tropics. The present study was carried out to detect the sharing antigens among the purified somatic antigens of G ...
R VIJAYASHANTHI +3 more
doaj +1 more source
Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells. [PDF]
PLoS ONE, 2012 The induction of relatively weak immunity by DNA vaccines in humans can be largely attributed to the low efficiency of transduction of somatic cells. Although formulation with liposomes has been shown to enhance DNA transduction of cultured cells, little,
Shuang Geng +9 more
doaj +1 more source
The Serological Specificities of Pasteurella pseudotuberculosis Somatic Antigens [PDF]
Journal of General Microbiology, 1958 SUMMARY: The serological specificities of lipopolysaccharides obtained from representatives of each of the five serological groups of Pasteurella pseudotuberculosis have been examined by haemagglutination methods. At concentrations of 500 μg./ml. solutions of the lipopolysaccharides failed to give full sensitization of erythrocytes, but after treatment
M J, CRUMPTON +2 more
openaire +2 more sources
"Enzyme-Linked Immunotransfer Blot Analysis of Somatic and Excretory- Secretory Antigens of Fasciola hepatica in Diagnosis of Human Fasciolosis" [PDF]
Iranian Journal of Public Health, 2004 The liver fluke Fasciola hepatica causes fascioliasis, a liver disease in most part of the world and particularly in north of Iran. Diagnosis of the diseases is anchored in coprological manner but serological methods are preferable due to some ...
MB Rokni +3 more
doaj +2 more sources
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]
, 2006 Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf +23 more
core +1 more source
Mechanisms behind Functional Avidity Maturation in T Cells
Clinical and Developmental Immunology, 2012 During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell ...
Marina Rode von Essen +2 more
doaj +1 more source
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation
Nature Communications, 2023 Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens.
Simona Pagliuca +16 more
doaj +1 more source
Secondary Mechanisms of Affinity Maturation in the Human Antibody Repertoire
Frontiers in Immunology, 2013 V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges.
Bryan S. Briney, James E. Crowe
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source