Paramphistomosis is the emerging fluke infection in young ruminants which results in high morbidity and mortality in tropics and sub-tropics. The present study was carried out to detect the sharing antigens among the purified somatic antigens of G ...
R VIJAYASHANTHI +3 more
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Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells. [PDF]
The induction of relatively weak immunity by DNA vaccines in humans can be largely attributed to the low efficiency of transduction of somatic cells. Although formulation with liposomes has been shown to enhance DNA transduction of cultured cells, little,
Shuang Geng +9 more
doaj +1 more source
The Serological Specificities of Pasteurella pseudotuberculosis Somatic Antigens [PDF]
SUMMARY: The serological specificities of lipopolysaccharides obtained from representatives of each of the five serological groups of Pasteurella pseudotuberculosis have been examined by haemagglutination methods. At concentrations of 500 μg./ml. solutions of the lipopolysaccharides failed to give full sensitization of erythrocytes, but after treatment
M J, CRUMPTON +2 more
openaire +2 more sources
"Enzyme-Linked Immunotransfer Blot Analysis of Somatic and Excretory- Secretory Antigens of Fasciola hepatica in Diagnosis of Human Fasciolosis" [PDF]
The liver fluke Fasciola hepatica causes fascioliasis, a liver disease in most part of the world and particularly in north of Iran. Diagnosis of the diseases is anchored in coprological manner but serological methods are preferable due to some ...
MB Rokni +3 more
doaj +2 more sources
Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [PDF]
Western blot analysis using an anti-globin rabbit serum Rb94 revealed a major band of 17 kDa in extracts of Ostertagia ostertagi adults and 4th-stage larvae.
De Marez, Tine +16 more
core +1 more source
Mechanisms behind Functional Avidity Maturation in T Cells
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell ...
Marina Rode von Essen +2 more
doaj +1 more source
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation
Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens.
Simona Pagliuca +16 more
doaj +1 more source
Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome [PDF]
Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response.
G Steinhauser +9 more
core +1 more source
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf +23 more
core +1 more source
Secondary Mechanisms of Affinity Maturation in the Human Antibody Repertoire
V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges.
Bryan S. Briney, James E. Crowe
doaj +1 more source

