Results 41 to 50 of about 938,133 (296)

Pramef12 enhances reprogramming into naïve iPS cells

Biochemistry and Biophysics Reports, 2022
Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by forced expression of the transcription factors Oct3/4, Klf4, Sox2, and c-Myc (OKSM).
Daiki Haraguchi, Toshinobu Nakamura
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Yiannis Ioannou, Lambrianides, A., Anisur Rahman, Isenberg, D.A., Lesley Mason, Giles, I., Ioannou, Y., Latchman, D.S., Mason, L., Jessica J. Manson, Ian Giles, Manson, J.J., David A. Isenberg, David S. Latchman, Rahman, A., Anastasia Lambrianides   +15 more
core   +1 more source

Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus [PDF]

, 1986
Long-term cytolytic T-lymphocyte (CTL) lines that are specific for distinct antigens associated with different phases of the replicative cycle of the murine cytomegalovirus (MCMV) were established by cloning of CTL lines derived from lymph nodes of ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Bühring, Hans-Jörg   +2 more
core   +1 more source

Preparation of Somatic Antigen from Fusarium Solani for Serological Diagnosis of Fusariosis

پزشکی بالینی ابن سینا, 2005
Introduction & Objective: Fusariosis is one of the most important systemic mycosis, often caused by Fusarium Solani and resist to antifungal drugs. The appropriate F. Solani antigen preparation could be useful in serodiagnosis of fusariosis.  Materials &
Mohammad Reza Aghamirian, Farideh Zaini
doaj  

Somatic Host Cell Alterations in HPV Carcinogenesis

Viruses, 2017
High-risk human papilloma virus (HPV) infections cause cancers in different organ sites, most commonly cervical and head and neck cancers. While carcinogenesis is initiated by two viral oncoproteins, E6 and E7, increasing evidence shows the importance of
Tamara R. Litwin, Megan A. Clarke, Michael Dean, Nicolas Wentzensen   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Serodiagnosis of Oesophagostomum Columbianum infection in Goats using indirect ELISA [PDF]

Veterinary World, 2011
To determine the seroprevalence of Oesophagostomum columbianum antibodies in goats in Kashmnir, a study was conducted in Srinagar and Ganderbal Districts, located in central parts of Kashmir valley.
Fayaz Ahmad, M. Z. Chisti, Bashir Ahmad Lone, Hidayatullah Tak   +3 more
doaj  

Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

Frontiers in Immunology, 2018
Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies.
Pauline A. van Schouwenburg, Hanna IJspeert, Ingrid Pico-Knijnenburg, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm, P. Martin van Hagen, P. Martin van Hagen, David van Zessen, Andrew P. Stubbs, Smita Y. Patel, Mirjam van der Burg   +10 more
doaj   +1 more source