Results 41 to 50 of about 578,208 (247)

Generation of Sheep Induced Pluripotent Stem Cells With Defined DOX-Inducible Transcription Factors via piggyBac Transposition

Frontiers in Cell and Developmental Biology, 2021
Pluripotent stem cells (PSCs) have the potential to differentiate to all cell types of an adult individual and are useful for studying mammalian development.
Moning Liu, Lixia Zhao, Lixia Zhao, Zixin Wang, Hong Su, Tong Wang, Guang Yang, Lu Chen, Baojiang Wu, Gaoping Zhao, Jitong Guo, Zhiqing Yang, Jia Zhang, Chunxia Hao, Teng Ma, Yongli Song, Siqin Bao, Yongchun Zuo, Xihe Li, Xihe Li, Guifang Cao   +20 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila [PDF]

, 2014
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
David R. Cavanagh, Hartmann Marcus W. W., Eleni-Muus Janna, Graeme J M Cowan, Ingo Aldag, Hartmann, Marcus W W, Samuel, Kay, Aldag Ingo, Samuel Kay, Alison M Creasey, Bockau, Ulrike, Cavanagh, David R, Alison M. Creasey, Creasey Alison M., Eleni-Muus, Janna, Cavanagh David R., Graeme J. M. Cowan, Cowan, Graeme J M; id_orcid, Ulrike Bockau, David R Cavanagh, Creasey, Alison M, Kay Samuel, Cowan Graeme J. M., Aldag, Ingo, Janna Eleni-Muus, Marcus W. W. Hartmann, Marcus W W Hartmann, Bockau Ulrike   +27 more
core   +2 more sources

Pramef12 enhances reprogramming into naïve iPS cells

Biochemistry and Biophysics Reports, 2022
Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by forced expression of the transcription factors Oct3/4, Klf4, Sox2, and c-Myc (OKSM).
Daiki Haraguchi, Toshinobu Nakamura
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life [PDF]

, 2007
Friedreich ataxia (FRDA) patients are homozygous for expanded GAA triplet-repeat alleles in the FXN gene. Primary neurodegeneration involving the dorsal root ganglia (DRG) results in progressive ataxia.
Ramussen, A, De Biase, Irene, Monticelli, A, Bidichandani, Sanjay I., De Biase, I, Al-Mahdawi, S, Pook, Mark, Cocozza, S, Al-Mahdawi, Sahar, Pook, M A, Bidichandani, S, Monticelli, Antonella, Rasmussen, Astrid, Cardone MF, RASMUSSEN A, D'ADDABBO, PIETRO, Teti MG, POOK M, Misceo D, MONTICELLI A, ARCHIDIACONO, Nicoletta, VENTURA, MARIO, BIDICHANDANI SI, ROCCHI, Mariano, COCOZZA, SERGIO, Capozzi O, Lomiento M, DE BIASE I, AL MAHDAWI S, Roberto R   +29 more
core   +1 more source

The Carcinoembryonic Antigen Gene Family [PDF]

, 1988
The molecular cloning of carcinoembryonic antigen (CEA) and several cross-reacting antigens reveals a basic domain structure for the whole family, which shows structural similarities to the immunoglobulin superfamily.
Zimmermann, Wolfgang, Thompson, John A.
core   +1 more source

Somatic Host Cell Alterations in HPV Carcinogenesis

Viruses, 2017
High-risk human papilloma virus (HPV) infections cause cancers in different organ sites, most commonly cervical and head and neck cancers. While carcinogenesis is initiated by two viral oncoproteins, E6 and E7, increasing evidence shows the importance of
Tamara R. Litwin, Megan A. Clarke, Michael Dean, Nicolas Wentzensen   +3 more
doaj   +1 more source

Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma

Frontiers in Immunology, 2022
BackgroundNeoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells.
Chongming Jiang, Evelien Schaafsma, Wei Hong, Yanding Zhao, Ken Zhu, Cheng-Chi Chao, Chao Cheng, Chao Cheng, Chao Cheng, Chao Cheng   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source