Results 31 to 40 of about 938,133 (296)

Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [PDF]

, 1996
Western blot analysis using an anti-globin rabbit serum Rb94 revealed a major band of 17 kDa in extracts of Ostertagia ostertagi adults and 4th-stage larvae.
De Marez, Tine, Blaxter, Mark L, Berghen, Paul, Raes, Stefaan, Blaxter, M. L., de Marez, T. M., Berghen, P., de Marez, T.M., Vercruysse, J., de Graaf, Dirk, Raes, S., Vercruysse, Jozef, Moens, L., de Graaf, D.C., Moens, Luc, Blaxter, M.L., de Graaf, D. C., M. L. Blaxter, J. Vercruysse, P. Berghen, L. Moens, S. Raes, T. M. De Marez, D. C. De Graaf   +23 more
core   +1 more source

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

mBio, 2011
The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 ...
Jens C. Krause, Damian C. Ekiert, Terrence M. Tumpey, Patricia B. Smith, Ian A. Wilson, James E. Crowe   +5 more
doaj   +1 more source

Defining the recognition elements of Lewis Y-reactive antibodies. [PDF]

PLoS ONE, 2014
Antibody response to carbohydrate antigens is often independent of T cells and the process of affinity/specificity improvement is considered strictly dependent on the germinal centers. Antibodies induced during a T cell-independent type 2 (TI-2) response
Somdutta Saha, Anastas Pashov, Eric R Siegel, Ramachandran Murali, Thomas Kieber-Emmons   +4 more
doaj   +1 more source

The Smooth and Rough Somatic Antigens of Pasteurella pseudotuberculosis [PDF]

Journal of General Microbiology, 1958
SUMMARY: From strains of Pasteurella pseudotuberculosis representing each of the five serological groups and some ‘Rough’ forms, lipopolysaccharides were isolated after disintegration of acetone-dried saline extracted organisms with phenol. The materials appear to carry the specificities on which the serological classification of the species is based ...
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Biology Direct, 2006
It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies.
Zhou Jianhui, Reason Donald C
doaj   +1 more source

Generation of Sheep Induced Pluripotent Stem Cells With Defined DOX-Inducible Transcription Factors via piggyBac Transposition

Frontiers in Cell and Developmental Biology, 2021
Pluripotent stem cells (PSCs) have the potential to differentiate to all cell types of an adult individual and are useful for studying mammalian development.
Moning Liu, Lixia Zhao, Lixia Zhao, Zixin Wang, Hong Su, Tong Wang, Guang Yang, Lu Chen, Baojiang Wu, Gaoping Zhao, Jitong Guo, Zhiqing Yang, Jia Zhang, Chunxia Hao, Teng Ma, Yongli Song, Siqin Bao, Yongchun Zuo, Xihe Li, Xihe Li, Guifang Cao   +20 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source