Results 31 to 40 of about 267,878 (327)
Italian Journal of Animal Science, 2010 This study was conducted to evaluate the timing of cleavage and blastocoel formation of in vitro fertilized and nuclear transfer embryos and to compare the efficiency of in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) techniques in ...
L.C. Cruz +5 more
doaj +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Biotechnological bases of the development of cloned pig embryos
Вавиловский журнал генетики и селекции, 2019 The term ‘clone’ in animal biotechnology refers to an organism derived from non-sexual reproduction, which is both a direct offspring and a genetic copy of the parent organism.
A. V. Lopukhov +2 more
doaj +1 more source
Study on Embryo Transfer System for Production of Transgenic Pigs
Journal of Animal Reproduction and Biotechnology, 2015 In the last 10 years, porcine somatic cell nuclear transfer to generate transgenic pig has been performed tremendous development with introduction and knockout of many genes.
Seungwon Na +10 more
doaj +1 more source
Epigenetic manipulation to improve mouse SCNT embryonic development
Frontiers in Genetics, 2022 Cloned mammals can be achieved through somatic cell nuclear transfer (SCNT), which involves reprogramming of differentiated somatic cells into a totipotent state. However, low cloning efficiency hampers its application severely.
Yamei Li +5 more
doaj +1 more source
Functional consequences of mitochondrial mismatch in reconstituted embryos and offspring
The Journal of Reproduction and Development, 2019 Animal cloning technology has been developed to produce progenies genetically identical to a given donor cell. However, in nuclear transfer protocols, the recipient oocytes contribute a heritable mitochondrial genomic (mtDNA) background to the progeny ...
Kumiko TAKEDA
doaj +1 more source
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer [PDF]
Cell, 2018 Generation of genetically uniform non-human primates may help to establish animal models for primate biology and biomedical research. In this study, we have successfully cloned cynomolgus monkeys (Macaca fascicularis) by somatic cell nuclear transfer (SCNT).
Qiang Sun +10 more
openaire +5 more sources
Interspecies Somatic Cell Nuclear Transfer: Advancements and Problems [PDF]
Cellular Reprogramming, 2013 Embryologists working with livestock species were the pioneers in the field of reprogramming by somatic cell nuclear transfer (SCNT). Without the "Dolly experiment," the field of cellular reprogramming would have been slow and induced plutipotent cells (iPSCs) would not have been conceived.
Lagutina, I. +3 more
openaire +4 more sources
Propagation of weakly advantageous mutations in cancer cell population [PDF]
arXiv, 2023 Research into somatic mutations in cancer cell DNA and their role in tumour growth and progression between successive stages is crucial for improving our understanding of cancer evolution. Mathematical and computer modelling can provide valuable insights into the scenarios of cancer growth, the roles of somatic mutations, and the types and strengths of
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source