Results 131 to 140 of about 546,473 (236)

A Study on the Uniform Distribution and Counting Method of Raw Cow's Milk Somatic Cells. [PDF]

Micromachines (Basel), 2022
Zhou W, Li X, Su W, Zheng H, An G, Li Z, Li S.   +6 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Highly efficient construction of monkey blastoid capsules from aged somatic cells. [PDF]

Nat Commun
Wu J, Shao T, Tang Z, Liu G, Li Z, Shi Y, Kang Y, Zuo J, Zhao B, Hu G, Liu J, Ji W, Zhang L, Niu Y.   +13 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs. [PDF]

Cell Rep
Cates K, Yuan L, Yang Y, Yoo AS.
europepmc   +1 more source

UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells. [PDF]

Life Sci Alliance, 2023
Chen C, Shen Y, Li L, Ren Y, Wang ZQ, Li T.   +5 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Mitochondrial DNA mosaicism in normal human somatic cells. [PDF]

Nat Genet
An J, Nam CH, Kim R, Lee Y, Won H, Park S, Lee WH, Park H, Yoon CJ, An Y, Kim JH, Jun JK, Bae JM, Shin EC, Kim B, Cha YJ, Kwon HW, Oh JW, Park JY, Kim MJ, Ju YS.   +20 more
europepmc   +1 more source

Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. [PDF]

Nat Commun, 2023
Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, Ogi T, Nakada S.   +7 more
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source