Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation [PDF]
, 2003 Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response.
Batista FD +36 more
core +3 more sources
Induced pluripotent stem cells, a giant leap for mankind therapeutic applications [PDF]
, 2019 Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging.
Bragança, José +3 more
core +1 more source
Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Allen RC +9 more
core +3 more sources
Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis [PDF]
, 2020 The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T.
Bublys, Kasparas +4 more
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A cancer cell-line titration series for evaluating somatic classification. [PDF]
, 2015 BackgroundAccurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task.
Beck, Timothy +7 more
core +2 more sources
Tissue culture of oil palm : finding the balance between mass propagation and somaclonal variation [PDF]
, 2019 The oil palm (Elaeis guineensis Jacq.) is typically propagated in vitro by indirect somatic embryogenesis, a process in which somatic cells of an explant of choice are, via an intermediate phase of callus growth, induced to differentiate into somatic ...
Inzé, Dirk, Maene, Ludo, Weckx, Sylvie
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Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]
, 2017 Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick +12 more
core +1 more source
Sex-related differences in death control of somatic cells [PDF]
, 2013 In 2001, The United States Institute of Medicine (IOM) Committee on Understanding the Biology of Sex and Gender Differences concluded that ‘Sex…should be considered when designing and analysing studies in all areas and at all levels of biomedical and ...
FILIPPINI, Antonio +3 more
core +2 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Nature, 1976 Variation, Senescence and Neoplasia in Cultured Somatic Cells. (A Commonwealth Fund Book.) By John W. Little-field. Pp. xi+163. (Harvard University: Cambridge, Massachusetts and London, 1976.) £6.15.
openaire +2 more sources