Results 111 to 120 of about 280,773 (255)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

PLoS Pathogens, 2013
Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination.
D. Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, J. Julien, Bryan S. Briney, A. Ramos, Karen Saye, Khoa Le, Alison E. Mahan, Shenshen Wang, M. Kardar, Gur Yaari, L. Walker, B. Simen, Elizabeth P. St. John, P. Chan-Hui, K. Swiderek, S. Kleinstein, G. Alter, M. Seaman, A. Chakraborty, D. Koller, I. Wilson, G. Church, D. Burton, P. Poignard   +27 more
semanticscholar   +1 more source

Multi‐Omic Profiling of T Cell‐Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This study integrates bulk and single‐cell RNA‐seq data to reveal significant B cell receptor (BCR) repertoire expansion, especially IgG isotype amplification, in T cell‐mediated rejection (TCMR) after kidney transplantation. Multi‐omic integration identifies plasma cells as the main BCR carriers in graft tissue and MEI1 as a key regulator promoting ...
He Zhang, Di Zhang, Yuhong Hu, Hao Zhang, Zijian Zhang, Xiaopeng Hu   +5 more
wiley   +1 more source

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Journal of Experimental Medicine, 2013
Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
Pauline Rouaud, C. Vincent-Fabert, A. Saintamand, Rémi Fiancette, M. Marquet, I. Robert, B. Reina-San-Martin, E. Pinaud, M. Cogné, Y. Denizot   +9 more
semanticscholar   +1 more source

Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. [PDF]

, 1998
Y Qin, Pierre Duquette, Y Zhang, Pierre J. Talbot, Robin Poole, Jack P. Antel   +5 more
openalex   +1 more source

Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Biology Direct, 2006
It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies.
Zhou Jianhui, Reason Donald C
doaj   +1 more source

Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse

Haematologica, 2013
In follicular lymphoma, somatic hypermutation of the immunoglobulin heavy chain genes facilitates the identification of different lymphoma cell clones, and the construction of genealogical trees.
Martin Wartenberg, P. Vasil, Christian Meyer zum Bueschenfelde, G. Ott, A. Rosenwald, F. Fend, M. Kremer   +6 more
semanticscholar   +1 more source

Data from A Hypermutation Phenotype and Somatic <i>MSH6</i> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

, 2023
Chris Hunter, Raffaella Smith, Daniel P. Cahill, Philip Stephens, Claire E. Stevens, Jon W. Teague, Chris Greenman, Sarah Edkins, Graham R. Bignell, Helen Davies, Sarah O’Meara, Adrian G. Parker, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, Andy Jenkinson, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, David J. Richardson, Rebecca Shepherd, Alexandra Small, Helen Solomon, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Douglas F. Easton, Gregory J. Riggins, Jennifer E. Roy, Kymberly K. Levine, Wolf Mueller, Tracy T. Batchelor, David N. Louis, Michael R. Stratton, P. Andrew Futreal, Richard Wooster   +54 more
openalex   +1 more source

Rod‐Like Cytoplasmic Inclusions in the Peripheral Blood Smear of a Patient with Chronic Lymphocytic Leukemia

eJHaem, Volume 7, Issue 1, February 2026.
Abhishek Prasad, Tran B. Nguyen, Luis F. Carrillo   +2 more
wiley   +1 more source

Figure S1 from Somatic Hypermutation of the <i>YAP</i> Oncogene in a Human Cutaneous Melanoma

, 2023
Xiaomeng Zhang, Jian Tang, Ismael A. Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew J. Colebatch, Lachlan McIntosh, Katrina A. Mitchell, Evangeline Shaw, Helen Rizos, Georgina V. Long, Nicholas K. Hayward, Grant A. McArthur, Anthony T. Papenfuss, Kieran F. Harvey, Mark Shackleton   +17 more
openalex   +1 more source

Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

Journal of Experimental Medicine, 2013
Ongoing transcription of the Ig gene coupled with temporary pausing within the targeted region facilitates somatic hypermutation.
Prashant Kodgire, Priyanka Mukkawar, Sarayu Ratnam, T. Martin, U. Storb   +4 more
semanticscholar   +1 more source