Results 121 to 130 of about 280,773 (255)

Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells [PDF]

, 2002
Hirochika Toyama, Seiji Okada, Masahiko Hatano, Yoshimasa Takahashi, Nobue Takeda, Hirohito Ichii, Toshitada Takemori, Yoshikazu Kuroda, Takeshi Tokuhisa   +8 more
openalex   +1 more source

Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability

Cell Reports, 2019
Summary: Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms ...
Laila Shehata, Daniel P. Maurer, Anna Z. Wec, Asparouh Lilov, Elizabeth Champney, Tingwan Sun, Kimberly Archambault, Irina Burnina, Heather Lynaugh, Xiaoyong Zhi, Yingda Xu, Laura M. Walker   +11 more
doaj   +1 more source

Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation [PDF]

, 2008
Alexander Deutsch, Margareta Frühwirth, Ariane Aigelsreiter, Lorenzo Cerroni, Peter Neumeister   +4 more
openalex   +1 more source

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. [PDF]

J Immunol, 2023
Schrader CE, Williams T, Pechhold K, Linehan EK, Tsuchimoto D, Nakabeppu Y.   +5 more
europepmc   +1 more source

Analysis of VH Gene Rearrangement and Somatic Hypermutation in Sjogren’s Syndrome and IgG4‐Related Sclerosing Sialadenitis [PDF]

, 2010
Hidenori Sakuma, Fumihiko Okumura, Satoru Miyabe, Masayuki Sugiura, Takashi Joh, Kazuo Shimozato, Hiroshi Inagaki   +6 more
openalex   +1 more source

B Cell–Intrinsic mTORC1 Promotes Germinal Center–Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity [PDF]

, 2018
Ariel Raybuck, Sung Hoon Cho, Jingxin Li, Meredith C. Rogers, Keunwook Lee, Christopher L. Williams, Mark J. Shlomchik, James W. Thomas, Jin Chen, John V. Williams, Mark Boothby   +10 more
openalex   +1 more source

Single-Step IGHV Next-Generation Sequencing Detects Clonality and Somatic Hypermutation in Lymphoid Malignancies: A Phase III Diagnostic Accuracy Study. [PDF]

Cancers (Basel), 2023
Gazzola A, Navari M, Mannu C, Donelli R, Etebari M, Piccaluga PP.   +5 more
europepmc   +1 more source

One-step generation of monoclonal B cell receptor mice capable of class switch recombination and somatic hypermutation [PDF]

, 2017
Johanne T. Jacobsen, Luka Mesin, Styliani Markoulaki, Cecília B. Cavazzoni, Djenet Bousbaine, Rudolf Jaenisch, Gabriel D. Victora   +6 more
openalex   +1 more source

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation. [PDF]

Front Immunol, 2023
Martin OA, Thomas M, Marquet M, Bruzeau C, Garot A, Brousse M, Bender S, Carrion C, Choi JE, Vuong BQ, Gearhart PJ, Maul RW, Le Noir S, Pinaud E.   +13 more
europepmc   +1 more source

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity. [PDF]

Front Oncol, 2022
Sofou E, Zaragoza-Infante L, Pechlivanis N, Karakatsoulis G, Notopoulou S, Stavroyianni N, Psomopoulos F, Georgiou E, de Septenville AL, Davi F, Agathangelidis A, Chatzidimitriou A, Stamatopoulos K.   +12 more
europepmc   +1 more source