Results 31 to 40 of about 280,773 (255)

Somatic hypermutation signature in B-cell low-grade lymphomas

Haematologica, 2008
Background Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal ...
Lorraine Tracey, Mohit Aggarwal, Mónica García-Cosio, Raquel Villuendas, Patrocinio Algara, Margarita Sánchez-Beato, Abel Sánchez-Aguilera, Juan F. García, Antonia Rodríguez, Francisca I. Camacho, Nerea Martínez, Elena Ruiz-Ballesteros, Manuela Mollejo, Miguel Á. Piris   +13 more
doaj   +1 more source

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. [PDF]

PLoS Biology, 2004
Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Hiroshi Arakawa, Huseyin Saribasak, Jean-Marie Buerstedde   +2 more
doaj   +1 more source

kataegis: an R package for identification and visualization of the genomic localized hypermutation regions using high-throughput sequencing

BMC Genomics, 2021
Background Genomic localized hypermutation regions were found in cancers, which were reported to be related to the prognosis of cancers. This genomic localized hypermutation is quite different from the usual somatic mutations in the frequency of ...
Xue Lin, Yingying Hua, Shuanglin Gu, Li Lv, Xingyu Li, Pin Chen, Peng Dai, Yunyun Hu, Anna Liu, Jian Li   +9 more
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Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Cell Reports, 2018
Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski, Stacey A. Cranert, Julian Q. Zhou, Heping Xu, Steven H. Kleinstein, Harinder Singh, Stephen N. Waggoner   +6 more
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Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Nature Communications, 2023
In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase ...
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang   +38 more
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V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

Frontiers in Immunology, 2018
An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions.
Philip A. Leighton, Jacqueline Morales, William D. Harriman, Kathryn H. Ching   +3 more
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Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia

Scientific Reports, 2021
The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients.
Crescenzio Francesco Minervini, Cosimo Cumbo, Immacolata Redavid, Maria Rosa Conserva, Paola Orsini, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Giuseppina Tota, Luciana Impera, Elisa Parciante, Francesco Tarantini, Annamaria Giordano, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +15 more
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Genome-wide somatic hypermutation [PDF]

Proceedings of the National Academy of Sciences, 2004
DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci.
Clifford L, Wang, Ryan A, Harper, Matthias, Wabl   +2 more
openaire   +2 more sources

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

Frontiers in Immunology, 2023
The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem.
Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez Carreon, Elba A. Turbat-Herrera, Elba A. Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz Zamora   +6 more
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Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Frontiers in Immunology, 2022
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments.
Matheus Oliveira de Souza, Matheus Oliveira de Souza, Bharat Madan, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S. Fahad, Sheila N. Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T. Yin, Tongqing Zhou, David D. Ho, Peter D. Kwong, Peter D. Kwong, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky   +20 more
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