Results 41 to 50 of about 280,773 (255)
Frontiers in Immunology, 2017 A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties ...
Kazutaka Kitaura +5 more
semanticscholar +1 more source
Haematologica, 2008 Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi +9 more
doaj +1 more source
Runtime Analysis of Somatic Contiguous Hypermutation Operators in MOEA/D Framework
AAAI Conference on Artificial Intelligence, 2020 Somatic contiguous hypermutation (CHM) operators are important variation operators in artificial immune systems. The few existing theoretical studies are only concerned with understanding the optimization behavior of CHM operators on solving single ...
Zhengxin Huang, Yuren Zhou
semanticscholar +1 more source
Frontiers in Immunology, 2018 Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov +25 more
doaj +1 more source
Frontiers in Immunology, 2017 Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding ...
Zizhang Sheng +7 more
semanticscholar +1 more source
Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma
Molecular Cancer Research, 2019 Melanoma is usually driven by mutations in BRAF or NRAS, which trigger hyperactivation of MAPK signaling. However, MAPK-targeted therapies are not sustainably effective in most patients.
Xiaomeng Zhang +17 more
semanticscholar +1 more source
Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden
Frontiers in Oncology, 2021 BackgroundTumor mutation burden has been proven to be a good predictor for the efficacy of immunotherapy, especially in patients with hypermutation. However, most research focused on the analysis of hypermutation in individual tumors, and there is a lack
Hong Yuan +13 more
doaj +1 more source
AID and Somatic Hypermutation [PDF]
, 2010 In response to an assault by foreign organisms, peripheral B cells can change their antibody affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify its DNA is exceptional in light of the potential consequences of genetic alterations to cause human disease and cancer. Thus, as expected, this mechanism of antibody
Robert W, Maul, Patricia J, Gearhart
openaire +2 more sources
Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
Frontiers in Immunology, 2018 The evolution of antibodies in an individual during an immune response by somatic hypermutation (SHM) is essential for the ability of the immune system to recognize and remove the diverse spectrum of antigens that may be encountered.
Chaim A. Schramm, D. Douek
semanticscholar +1 more source
Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer
Molecular Systems BiologySomatic hypermutation in cancer has gained momentum with the increased use of tumour mutation burden as a biomarker for immune checkpoint inhibitors.
Aidan Flynn +2 more
doaj +1 more source