Results 81 to 90 of about 280,773 (255)

Somatic hypermutation and B–cell lymphoma [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
During the B–cell response to T–cell–dependent antigens, the B cells undergo a rapid proliferative phase in the germinal centre. This is accompanied by the introduction of mutations into the immunoglobulin (Ig) variable region (V) genes. The B cells are then selected according to the affinity of the encoded immunoglobulin for antigen, resulting in ...
Dunn-Walters, D, Thiede, C, Alpen, B, Spencer, J   +3 more
openaire   +2 more sources

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

IgG1 memory B cells keep the memory of IgE responses

Nature Communications, 2017
IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear.
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille, Maria A. Curotto de Lafaille   +14 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Somatic Hypermutation

Citation: 'somatic hypermutation' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11227 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Jana Ridani, Philip Barbulescu, Alberto Martin, Javier M. Di Noia   +3 more
openaire   +2 more sources

Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue

Nature Communications, 2018
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear.
Yuan Zhao, Mohamed Uduman, Jacqueline H. Y. Siu, Thomas J. Tull, Jeremy D. Sanderson, Yu-Chang Bryan Wu, Julian Q. Zhou, Nedyalko Petrov, Richard Ellis, Katrina Todd, Konstantia-Maria Chavele, William Guesdon, Anna Vossenkamper, Wayel Jassem, David P. D’Cruz, David J. Fear, Susan John, Dagmar Scheel-Toellner, Claire Hopkins, Estefania Moreno, Natalie L. Woodman, Francesca Ciccarelli, Susanne Heck, Steven H. Kleinstein, Mats Bemark, Jo Spencer   +25 more
doaj   +1 more source

Secondary Mechanisms of Affinity Maturation in the Human Antibody Repertoire

Frontiers in Immunology, 2013
V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges.
Bryan S. Briney, James E. Crowe
doaj   +1 more source

DNA repair in antibody somatic hypermutation [PDF]

Trends in Immunology, 2006
Somatic hypermutation (SHM) underlies the generation of a diverse repertoire of high-affinity antibodies. It is effected by a two-step process: (i) DNA lesions initiated by activation-induced cytidine deaminase (AID), and (ii) lesion repair by the combined intervention of DNA replication and repair factors that include mismatch repair (MMR) proteins ...
Paolo, Casali, Zsuzsanna, Pal, Zhenming, Xu, Hong, Zan   +3 more
openaire   +2 more sources

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source

Realization of immune response features by dynamical system models

Mathematical Biosciences and Engineering, 2007
Among the features of real immune responses that occur whenantigens invade a body are two remarkable features.One is that the number of antibodies produced in the secondary invasionby identical antigens is more than 10 times largerthan in the primary ...
Mika Yoshida, Kinji Fuchikami, Tatsuya Uezu   +2 more
doaj   +1 more source