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The Somatomedin Hypothesis: 2001 [PDF]
Endocrine Reviews, 2001 AbstractSince the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery
Shoshana Yakar, Jun-li Liu
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Iraqi Journal of Agricultural Sciences, 2023 Lambs’ performance and some carcass traits in relation to insulin-like growth factor-1 (IGF-1) were studied in twelve lambs from each of Awassi and Karadi slaughtered at three different weights raised at the animal farm, Department of Animal Production,
Khalil A. D. Oray
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Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B 1–44 Domain of Vitronectin [PDF]
PLoS ONE, 2010 Cyr61 is a member of the CCN (Cyr61, connective tissue growth, NOV) family of extracellular-associated (matricellular) proteins that present four distinct functional modules, namely insulin-like growth factor binding protein (IGFBP), von Willebrand ...
Ivo M B Francischetti +1 more
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Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury
Frontiers in Bioengineering and Biotechnology, 2021 Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative ...
Karim A Sarhane +2 more
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Estimation of Somatomedin-C Levels in Normals and Patients with Pituitary Disease by Radioimmunoassay [PDF]
Journal of Clinical Investigation, 1977 The development of a radioimmunoassay for somatomedin-C has for the first time made it possible to discriminate between serum concentrations of a single peptide or closely related group of peptides and the net somatomedin activity measured by less ...
Richard W. Furlanetto +3 more
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Acute abdominal pain due to atypical bilateral adrenal infarction in acute myeloid leukemia with alterations related to myelodysplasia: A case report. [PDF]
Clin Case Rep, 2023 Thoracoabdominal computed tomography with contrast enhancement on admission revealed diffusely enlarged bilateral adrenal glands with diffuse internal low‐attenuation areas. We report a case of abdominal pain and adrenal insufficiency due to AML‐induced adrenal infarction.
Hirata R +7 more
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REVIEW: The Somatomedin Hypothesis 2007: 50 Years Later
Journal of Clinical Endocrinology and Metabolism, 2007 Context: The somatomedin/IGF hypothesis was based on the observation that GH was inactive when added to an in vitro incubation system but required a GH-dependent substance in the circulation to mediate its activity. Newer experimental evidence has led to
Pinchas Cohen
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Primary structure of somatomedin B A growth hormone‐dependent serum factor with protease inhibiting activity [PDF]
, 1978 Linda Fryklund, Hans Sievertsson
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Somatomedin: Proposed Designation for Sulphation Factor [PDF]
Nature, 1972 William H. Daughaday +5 more
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