Results 1 to 10 of about 4,881 (194)
The Somatomedin Hypothesis: 2001 [PDF]
Endocrine Reviews, 2001 AbstractSince the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery
Shoshana Yakar, Jun-li Liu
exaly +7 more sources
Iraqi Journal of Agricultural Sciences, 2023 Lambs’ performance and some carcass traits in relation to insulin-like growth factor-1 (IGF-1) were studied in twelve lambs from each of Awassi and Karadi slaughtered at three different weights raised at the animal farm, Department of Animal Production,
Khalil A. D. Oray
exaly +3 more sources
Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B 1–44 Domain of Vitronectin [PDF]
PLoS ONE, 2010 Cyr61 is a member of the CCN (Cyr61, connective tissue growth, NOV) family of extracellular-associated (matricellular) proteins that present four distinct functional modules, namely insulin-like growth factor binding protein (IGFBP), von Willebrand ...
Ivo M B Francischetti +1 more
exaly +2 more sources
Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury
Frontiers in Bioengineering and Biotechnology, 2021 Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative ...
Karim A Sarhane +2 more
exaly +3 more sources
Functional structure of the somatomedin B domain of vitronectin [PDF]
Protein Science, 2007 Aiwu Zhou
exaly +2 more sources
Motor Neuron Diseases and Neuroprotective Peptides: A Closer Look to Neurons
Frontiers in Aging Neuroscience, 2021 Motor neurons (MNs) are specialized neurons responsible for muscle contraction that specifically degenerate in motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SBMA), and spinal muscular ...
Emanuela Zuccaro +7 more
doaj +1 more source
A Deletion Mutant of Vitronectin Lacking the Somatomedin B Domain Exhibits Residual Plasminogen Activator Inhibitor-1-binding Activity [PDF]
Journal of Biological Chemistry, 2008 Cynthia B Peterson
exaly +2 more sources
Equine Chorionic Gonadotropin Modulates the Expression of Genes Related to the Structure and Function of the Bovine Corpus Luteum. [PDF]
PLoS ONE, 2016 We hypothesized that stimulatory and superovulatory treatments, using equine chorionic gonadotropin (eCG), modulate the expression of genes related to insulin, cellular modelling and angiogenesis signaling pathways in the bovine corpus luteum (CL ...
Liza Margareth Medeiros de Carvalho Sousa +4 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 The age-related reduction in circulating levels of insulin-like growth factor-1 (IGF-1) is associated with increased risk of stroke and neurodegenerative diseases in advanced age.
Cellas A. Hayes +5 more
doaj +1 more source
Molecular cloning, expression, and functional features of IGF1 splice variants in sheep
Endocrine Connections, 2021 Insulin-like growth factor 1 (IGF1), also known as somatomedin C, is essential for the regulation of animal growth and development. In many species, the IGF1 gene can be alternatively spliced into multiple transcripts, encoding different pre-pro-IGF1 ...
Xu-Ting Song +10 more
doaj +1 more source