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Immunoreactive Somatomedin A in Human Serum*
The Journal of Clinical Endocrinology & Metabolism, 1979A RIA has been developed for somatomedin A (SM-A) utilizing Sepharose-bound antibodies. This assay, measuring SM-A, the insulin-like growth factors 1 and 2, and somatomedin C, allows determination in serum samples. In comparison with a serum standard, the mean serum levels in patients with acromegaly or GH deficiency and healthy subjects were 8.7 %/- 0.
Gösta Enberg +3 more
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Diabetes, 1983
Diabetics may have normal somatomedins by radioimmunoassay yet decreased somatomedin activity by bioassay. The discrepancy appears due to circulating inhibitory factors; inhibitors in whole diabetic serum antagonize the action of both somatomedins and insulin via noncompetitive interactions.
C K Matheson +3 more
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Diabetics may have normal somatomedins by radioimmunoassay yet decreased somatomedin activity by bioassay. The discrepancy appears due to circulating inhibitory factors; inhibitors in whole diabetic serum antagonize the action of both somatomedins and insulin via noncompetitive interactions.
C K Matheson +3 more
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A RAPID SIMPLIFIED BIOASSAY FOR SOMATOMEDIN
Journal of Endocrinology, 1978A simplified, more rapid bioassay for the estimation of somatomedin activity, based on the porcine costal cartilage bioassay, is described. A micro-scale system based on the porcine costal cartilage assay is also described. These assay systems showed no decrease in sensitivity or precision, compared with other methods, as a result of the modifications.
A. M. Taylor, G. S. G. Spencer
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Nutrition and somatomedin. XVII. Circulating somatomedin C during treatment of diabetic ketoacidosis
Diabetes, 1987Although somatomedin levels may be low in animals with experimental diabetes, values in humans have generally been normal. Because humans with severely decompensated diabetes have not been studied, we characterized somatomedin C responses during metabolic restoration in 21 patients with diabetic ketoacidosis.
Lawrence S. Phillips +2 more
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Molecular and Cellular Endocrinology, 1984
The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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1986
Somatomedins (SM) are defined as growth hormone (GH) dependent hormonal peptides mediating GH action.(1) The original observations that led to the postulate of such a growth factor in serum were made by Salmon and Daughaday in 1957.(2) Later, the originally proposed term “sulfation factor” was changed to “somatomedin.”(1) Three different SM fractions ...
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Somatomedins (SM) are defined as growth hormone (GH) dependent hormonal peptides mediating GH action.(1) The original observations that led to the postulate of such a growth factor in serum were made by Salmon and Daughaday in 1957.(2) Later, the originally proposed term “sulfation factor” was changed to “somatomedin.”(1) Three different SM fractions ...
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The Influence of Ballistic Exercises on Growth, Somatomedin Hormones for Soccer Players
Open Access Macedonian Journal of Medical Sciences, 2022Samed Soy
exaly