Results 31 to 40 of about 4,881 (194)
Proteomic exploration of potential blood biomarkers in haemophilic arthropathy
Health Science Reports, Volume 7, Issue 9, September 2024.Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota +13 more
wiley +1 more source
Aging Cell, Volume 23, Issue 9, September 2024.This study examined the effects of metformin (MF) and trodusquemine (MSI‐1436) on the livers of young, developing mice. We discovered that MSI‐1436 significantly alters mRNA and miRNA expression more potently than MF, impacting key metabolic pathways.
Sarah A. Ashiqueali +17 more
wiley +1 more source
Bioactive Materials, 2020 Biomaterial surface chemistry engenders profound consequences on cell adhesion and the ultimate tissue response by adsorbing proteins from extracellular matrix, where vitronectin (Vn) is involved as one of the crucial mediator proteins.
Tianjie Li +4 more
doaj
Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules
Small, Volume 20, Issue 21, May 23, 2024.A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon +6 more
wiley +1 more source
Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model
The FASEB Journal, Volume 38, Issue 6, 31 March 2024.Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic +5 more
wiley +1 more source
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні наукиDespite the evidence of the fundamental influence of the endocrine system on metabolism in ruminants, there is little literature on hormonal status. There is insufficient data on tissue hormones, particularly insulin-like growth factor and leptin.
M. R. Simonov +5 more
doaj +1 more source
Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew +2 more
wiley +1 more source
The biophysical and compositional properties of human basement membranes
The FEBS Journal, Volume 291, Issue 3, Page 477-488, February 2024.Basement membranes are exceptionally adaptable materials with both extremely stiff and highly elastic properties. This article highlights these features on a selection of human membranes and links them to compositional, biomechanical, and structural profiles down to a molecular level. The role of water in modulating these attributes is also scrutinized
Monica S. Schoenenberger +7 more
wiley +1 more source
Guidelines on diagnostics and treatment of acromegaly (draft)
Ожирение и метаболизмWe recommend acromegaly to be ruled in all patients with characteristic changes in appearance (A3). In all patients without characteristic changes in appearance, we recommend to rule out acromegaly, if several clinical signs suspicious for acromegaly are
E. G. Przhiyalkovskaya +25 more
doaj +1 more source
Quantification of insulin‐like growth factor‐I by liquid chromatography–mass spectrometry
Rapid Communications in Mass Spectrometry, Volume 38, Issue S1, January 2024.We describe three methods of sample preparation for the liquid chromatography coupled with mass spectrometric measurement of insulin‐like growth factor‐I concentration in blood. One method involves trypsin digestion, the second involves intact protein quantification and the third method is a combination of the first two.
Danielle A. Moncrieffe, David A. Cowan
wiley +1 more source