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How Does Physical Activity Modulate Hormone Responses? [PDF]

open access: yesBiomolecules
Mennitti C   +15 more
europepmc   +1 more source

The IGF System and Aging.

open access: yesEndocr Rev
Conover CA, Oxvig C.
europepmc   +1 more source
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Somatomedins

Medical Journal of Australia, 1975
An intact pituitary gland capable of secreting growth hormone has long been considered the prime requirement for the achievement of skeletal growth potential in man. Recent studies have revealed that the growth-promoting action of growth hormone is an in-vivo phenomenon which cannot be mimicked by the addition of the hormone to skeletal tissue in vitro.
K, Hall   +3 more
  +8 more sources

Somatomedin

Clinical Orthopaedics and Related Research, 1975
Somatomedin is a peptide component of serum which has been postulated to mediate the action of growth hormone on skeletal tissue. Direct effects on cartilage include stimulation of the synthesis of mucopolysacharide, protein, and nucleic acids. Insulin-like effects on non-skeletal tissues and cells have been described, and a relationship to NSILA-S and
J D, Bomboy, W D, Salmon
openaire   +2 more sources

Glucocorticoid Effects on Somatomedins and Somatomedin Inhibitors*

The Journal of Clinical Endocrinology & Metabolism, 1985
Glucocorticoid excess may be associated with poor growth despite normal levels of GH and adequate nutrition. Steroid-induced growth failure could be mediated by defective generation and/or action of somatomedins. To probe potential mechanisms, we examined the effect of corticosteroid administration on net somatomedin activity, immunoreactive ...
T G, Unterman, L S, Phillips
openaire   +2 more sources

Somatomedins and Steroids

Hormone Research, 1986
Somatomedin levels measured by radioreceptor assay, competitive protein-binding assay or radioimmunoassay are normal in hypercortisolism; the decrease of somatomedin activity consistently found in this condition is due to an increase in circulating somatomedin inhibitors resulting in an inhibition of somatomedin action. Progestagens could possibly have
Caufriez, Anne, Copinschi, Georges
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Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism

Hormone and Metabolic Research, 1980
It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
R G, Rosenfeld, R L, Hintz
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Nutrition and somatomedin XVI: Somatomedins and somatomedin inhibitors in fasted and refed rats

Metabolism, 1988
Nutritional deprivation is associated with poor growth and decreased levels of net circulating somatomedin activity, as measured by bioassay. Since somatomedin activity reflects the contributions both of somatomedins (which stimulate cartilage) and of somatomedin inhibitors (which antagonize the ability of the somatomedins to stimulate cartilage), we ...
L S, Phillips, S, Goldstein, J R, Gavin
openaire   +2 more sources

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