Results 281 to 290 of about 128,394 (306)
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Somatostatin, Somatostatin Receptors, and Pancreatic Cancer
World Journal of Surgery, 2005AbstractSomatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review.
Min Li +6 more
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Current Molecular Medicine, 2013
The pharmacological effects (i.e., inhibition of endocrine secretion and cell proliferation) mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity binding to five different G proteincoupled receptors (GPCRs), named sst1-5.
Ruscica M +4 more
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The pharmacological effects (i.e., inhibition of endocrine secretion and cell proliferation) mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity binding to five different G proteincoupled receptors (GPCRs), named sst1-5.
Ruscica M +4 more
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Cellular and Molecular Neurobiology, 1995
1. Somatostatin (SRIF) exerts diverse physiological actions in the body including regulation of hormone and neurotransmitter release and neuronal firing activity. Analogs of SRIF are used clinically to treat tumors and cancers and to block the hypersecretion of growth hormone in acromegaly. 2.
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1. Somatostatin (SRIF) exerts diverse physiological actions in the body including regulation of hormone and neurotransmitter release and neuronal firing activity. Analogs of SRIF are used clinically to treat tumors and cancers and to block the hypersecretion of growth hormone in acromegaly. 2.
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Metabolism, 1990
Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy.
Paavo Riekkinen, Asla Pitkänen
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Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy.
Paavo Riekkinen, Asla Pitkänen
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Trends in Endocrinology and Metabolism, 1985
It is now well established that the biological actions of tetradecapeptide somatostatin (somatostatin-14, S-14) are receptor-mediated. These receptors were first quantified in GH4C pituitary tumor cells using [125I-Tyr1] S-14 as radioligand which was found to exhibit high non-specific binding to membrane receptor preparations from normal tissues.
Y C, Patel, C B, Srikant
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It is now well established that the biological actions of tetradecapeptide somatostatin (somatostatin-14, S-14) are receptor-mediated. These receptors were first quantified in GH4C pituitary tumor cells using [125I-Tyr1] S-14 as radioligand which was found to exhibit high non-specific binding to membrane receptor preparations from normal tissues.
Y C, Patel, C B, Srikant
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Somatostatin and somatostatin receptors in fish growth
General and Comparative Endocrinology, 2010Multiple forms of somatostatin (SS) and SS receptors (SSTR) are produced widely in the tissues of fish and interact to coordinate numerous physiological processes. Insight into their role in growth regulation emerged from studies of abnormal growth and of whole animals.
Alison L. Hagemeister, Mark A. Sheridan
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[Somatostatin and somatostatin receptors in the prostate].
Minerva endocrinologica, 2001Somatostatin (st) exerts a role in the control of prostate growth and function acting both at hypothalamus-hypophysis level and at glandular level. St analogues have been used to control prostate cancer (CaP) in clinical trials, with contradictory results.
SINISI, Antonio Agostino +2 more
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Lung Cancer, 1993
Lung carcinoma is the most common cause of death in the western world and is increasing particularly among women. Despite significant developments in our understanding of the molecular biology of this disease our ability to treat the various subtypes of lung cancer has been at a relative standstill for the past decade.
K.J. O'Byrne, Desmond N. Carney
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Lung carcinoma is the most common cause of death in the western world and is increasing particularly among women. Despite significant developments in our understanding of the molecular biology of this disease our ability to treat the various subtypes of lung cancer has been at a relative standstill for the past decade.
K.J. O'Byrne, Desmond N. Carney
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Medical Clinics of North America, 1978
Somatostatin may act as a local regulator of endocrine and exocrine secretion and as a peptidergic neurotransmitter rather than as a classical circulating hormone. The possible physiologic role of its secretion in the regulation of islet A and B cell function, and particularly its significance in nutrient homeostasis and diabetes, are discussed.
Robert A. Rizza, John E. Gerich
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Somatostatin may act as a local regulator of endocrine and exocrine secretion and as a peptidergic neurotransmitter rather than as a classical circulating hormone. The possible physiologic role of its secretion in the regulation of islet A and B cell function, and particularly its significance in nutrient homeostasis and diabetes, are discussed.
Robert A. Rizza, John E. Gerich
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2016
Somatostatin (SS) was originally identified as a growth hormone (GH) inhibiting factor. Two forms of cyclic peptides, SS-14 and SS-28, are produced from a precursor encoded by the somatostatin 1 gene (SST). SS-14 is the predominant form in the brain, while SS-28 is mainly produced by intestinal enteroendocrine cells.
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Somatostatin (SS) was originally identified as a growth hormone (GH) inhibiting factor. Two forms of cyclic peptides, SS-14 and SS-28, are produced from a precursor encoded by the somatostatin 1 gene (SST). SS-14 is the predominant form in the brain, while SS-28 is mainly produced by intestinal enteroendocrine cells.
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