Results 111 to 120 of about 2,397,304 (343)

Molecular Imaging of Vulnerable Coronary Plaque with Radiolabeled Somatostatin Receptors (SSTR) [PDF]

, 2021
Luz Kelly Anzola, José Nelson Rivera, Juan Carlos Ramírez, Alberto Signore, Fernando Mut   +4 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Acromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly.
Denise Costa, Giada Giuliani, Valentina Martines, Chiara Pellicano, Valeria Mercuri, Vittorio Di Piero, Patrizia Gargiulo, Camilla Virili   +7 more
wiley   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Tumor-infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy. [PDF]

J Neuroendocrinol
Abstract Tumor‐infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors and cytokines. In this study, we assessed the effect of SRLs treatment on TICs.
Chiloiro S, Vicari A, Giampietro A, Mattogno PP, Cappoli N, Konini G, Calandrelli R, Lauretti L, Gaudino S, Rigante M, Rindi G, Olivi A, De Marinis L, Bianchi A, Doglietto F, Gessi M, Pontecorvi A.   +16 more
europepmc   +2 more sources

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Activation of somatostatin receptors attenuates pulmonary fibrosis [PDF]

, 2007
Raphaël Borie, Aurélie Fabre, Fabienne Prost, J. Marchal-Sommé, Rachida Lebtahi, S. Marchand‐Adam, Michel Aubier, P Soler, Bruno Crestani   +8 more
openalex   +1 more source

Somatostatin receptor scintigraphy with ⁶⁸Ga-DOTATATE PET/CT: initial experience in Cuba

Nucleus, 2017
In 1870, Rudolf Heidenhain discovered neuroendocrine cells, which can lead to the development of the Neuroendocrine Tumors (NER), a rare form of cancer, most of which express somatostatin receptors.
Juan P. Oliva González
doaj  

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, EarlyView.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source