Results 111 to 120 of about 39,903 (228)

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance. [PDF]

Nucl Med Commun
Gujral J, Gandhi OH, Amanullah AA, Singh SB, Ayubcha C, Patil S, Werner TJ, Revheim ME, Brem S, Alavi A.   +9 more
europepmc   +1 more source

Prolactin and Triiodothyronine Modulate Seasonal Variation in Brown Adipose Tissue in Djungarian Hamsters

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 7, Page 710-718, August 2026.
ABSTRACT Seasonal photoperiodic cycles regulate energy rheostasis in many animals. Brown adipose tissue (BAT) and the liver are key metabolic organs that show remarkable plasticity in response to photoperiodic conditions. Prolactin (PRL) and thyroid hormones are endocrine signals that transmit neural‐derived photoperiodic time measurement encoding to ...
Sayantan Sur, Grace Payling, Calum Stewart, Avalene Tan, Caitlin Diggle, Tyler J. Stevenson   +5 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Structural insights into nonpeptide antagonist inhibition of somatostatin receptor subtype 5. [PDF]

Proc Natl Acad Sci U S A
Li Y, Xing Z, Hu W, Wu K, Xu HE, Zhao LH.   +5 more
europepmc   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Somatostatin Receptor Expression of Gastroenteropancreatic Neuroendocrine Tumors: A Comprehensive Analysis in the Era of Somatostatin Receptor PET Imaging. [PDF]

Cancers (Basel)
Maratta MG, Al-Toubah T, Montilla-Soler J, Pelle E, Haider M, El-Haddad G, Strosberg J.   +6 more
europepmc   +1 more source

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1048-1060, August 2026.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

A Case of Primary Pulmonary Meningioma With Slow Enlargement Over a 9‐Year Period

Respirology Case Reports, Volume 14, Issue 8, August 2026.
Primary pulmonary meningioma (PPM) is an extremely rare benign tumour that often remains asymptomatic. Although most cases are incidentally detected as solitary pulmonary nodules on chest imaging, reports on their long‐term clinical courses remain limited. Herein, we report a case of PPM with slow growth over a nine‐year period.
Kazuki Sugata, Yoshitaka Tanaka, Hiroki Katsushima, Yoshio Tsunezuka   +3 more
wiley   +1 more source

Somatostatin receptor PET-guided treatment and artificial intelligence applications in meningioma: a comprehensive review. [PDF]

Am J Nucl Med Mol Imaging
Gujral J, Gandhi OH, Amanullah AA, Singh SB, Ayubcha C, Werner TJ, Revheim ME, Alavi A.   +7 more
europepmc   +1 more source