Results 141 to 150 of about 74,951 (264)

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Pancreatic Neuroendocrine Tumor Leading to a Diagnosis of Multiple Endocrine Neoplasia Type 1

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Pancreatic neuroendocrine neoplasms are rare but occasionally encountered. They are generally highly vascularized solid tumors, often round in shape with clear boundaries, defined contours, and a homogeneous internal structure. However, they can also present with atypical features, such as cystic degeneration, hemorrhage, calcification, and ...
Noriyuki Hirakawa, Katsuya Kitamura, Kei Yamamoto, Kenichi Tadokoro, Yasunosuke Akita, Jun Uemura, Fumito Yamanishi, Masakazu Abe, Munehide Nakatsugawa, Takao Itoi   +9 more
wiley   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Malignant Potential of Temporal Bone Paragangliomas With Reference to GAPP System

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
ABSTRACT Objectives To evaluate the temporal bone paragangliomas (so‐called glomus tumors, TB‐PGLs) via the Grading System for Adrenal Pheochromocytoma and Paraganglioma (GAPP) and succinate dehydrogenase subunit B (SDHB) immunohistochemistry, and to discuss their implications for postoperative follow‐up and treatment strategies. Methods This report is
Noritaka Komune, Midori Taniguchi, Yutaro Kida, Ryosuke Kuga, Daisuke Kuga, Koichi Arimura, Yoshinori Fujiwara, Hidetaka Yamamoto, Yoshinao Oda, Koji Yoshimoto, Takashi Nakagawa   +10 more
wiley   +1 more source

In vivo monitoring of a cAMP-stimulated DNA-binding activity [PDF]

, 1990
Boshart, Michael, Nitsch, Doris, Schlitz, Günther, Stewart, A. F., Weih, Falk   +4 more
core   +1 more source

Targeting Multiple Gut‐Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background As a disease of energy dysregulation, obesity involves metabolic, hormonal, and neural factors, the interconnection of which is referred to as the “gut‐brain axis.” Objective This review aimed to provide an overview of the clinical evidence of physiological and objective or subjective changes in eating behavior with gut hormone ...
Alexander D. Miras, Muzamil Hussain
wiley   +1 more source

Sub‐Anesthetic Ketamine Administration Decreases Deviance Detection Responses at the Cellular, Population‐ and Mesoscale Levels

European Journal of Neuroscience, Volume 63, Issue 7, April 2026.
During an auditory deviance detection task, naïve mice and mice injected with sub‐anesthetic ketamine show marked differences in spiking activity and mesoscale connectivity. Control mice exhibit a biphasic spiking response to deviant sounds, whereas the late spiking component is abolished by ketamine.
Maria Isabel Carreño‐Muñoz, Alessandra Ciancone Chama, Pegah Chehrazi, Bidisha Chattopadhyaya, Graziella Di Cristo   +4 more
wiley   +1 more source

Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler Mice Compared to Controls

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
In the habituation task, locomotion speed, whisker angular position and whisker spread decreased between the first two consecutive sessions in all mice, suggesting that the animals were less focused on sampling the area as they got more familiar with the environment.
Ugne Simanaviciute, Aybeniz Ece Cetin, Julien Guy, Helen Tams, Jochen Staiger, Robyn A. Grant   +5 more
wiley   +1 more source