Results 71 to 80 of about 39,903 (228)

SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors.

Folia Histochemica et Cytobiologica, 2010
The effectiveness of the long acting somatostatin analogues like octreotide and lanreotide depends on the expression of specific somatostatin receptors on the target cells.
Jolanta Kunert-Radek, Marek Pawlikowski, Hanna Pisarek, Robert Kubiak, Katarzyna Winczyk   +4 more
doaj   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Upregulation of Somatostatin Receptor Expression in Lactating Breast Shown in ^99mTc-HYNIC-TOC Scintigraphy

Diagnostics
A 31-year-old female patient with a 4-year history of multiple endocrine neoplasia type 1 (MEN1) presented with abdominal pain and weight loss that she had been experiencing over the past 6 months.
Mengyao Jia, Jie Feng, Yaping Luo
doaj   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response

Frontiers in Neuroscience, 2017
Corticotropin-releasing factor (CRF) is the hallmark brain peptide triggering the response to stress and mediates—in addition to the stimulation of the hypothalamus-pituitary-adrenal (HPA) axis—other hormonal, behavioral, autonomic and visceral ...
Andreas Stengel, Yvette F. Taché, Yvette F. Taché   +2 more
doaj   +1 more source

Endoscopic Treatment for Esophagogastric Variceal Bleeding in Patients With Acute‐on‐Chronic Liver Failure: An Observational Study

Portal Hypertension &Cirrhosis, EarlyView.
In patients with acute‐on‐chronic liver failure (ACLF), esophagogastric variceal bleeding (EGVB) represents a critical complication associated with high short‐term mortality. This study evaluated the efficacy of endoscopic treatment in this specific population and identified prognostic factors associated with 6‐week rebleeding and mortality.
Yanan Sun, Peng Li, Shibin Zhang, Yuening Zhang, Chunlei Fan, Ajuan Zeng, Yanna Liu, Huiguo Ding   +7 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source