Results 61 to 70 of about 1,293,690 (209)

Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4 [PDF]

, 2022
Somatostatin (also named as growth hormone-inhibiting hormone or somatotropin release-inhibiting factor) is a regulatory peptide important for the proper functioning of the endocrine system, local inflammatory reactions, mood and motor coordination, and ...
Börzsei, Rita, Csaba Hetényi, Bálint, Mónika, Balázs Zoltán Zsidó, Zsidó, Balázs Zoltán, Zsuzsanna Helyes, Helyes, Zsuzsanna, Hetényi, Csaba, Rita Börzsei, Mónika Bálint, Erika Pintér, Pintér, Erika   +11 more
core   +1 more source

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

An Update on DOTA-Peptides PET Imaging and Potential Advancements of Radioligand Therapy in Intracranial Meningiomas

Life
Meningiomas arise from the meningeal layers covering the central nervous system structures. Although most are benign, meningiomas can still cause neurological morbidity due to the mass effect and compression of the surrounding parenchyma.
Viviana Benfante, Ignazio Gaspare Vetrano, Muhammad Ali, Pierpaolo Purpura, Cesare Gagliardo, Paola Feraco, Costanza Longo, Tommaso Vincenzo Bartolotta, Patrizia Toia, Oriana Calisto, Albert Comelli, Massimo Midiri, Pierpaolo Alongi   +12 more
doaj   +1 more source

Nonpeptide somatostatin receptor agonists specifically target ocular neovascularization via the somatostatin type 2 receptor

, 2008
PURPOSE: To define the molecular pharmacology underlying the antiangiogenic effects of nonpeptide imidazolidine-2,4-dione somatostatin receptor agonists (NISAs) and evaluate the efficacy of NISA in ocular versus systemic delivery routes in ocular disease
Shaw, Lynn C, Palii, Stela S, Tan, Yufei, Reubi, Jean-Claude, Geroski, Dayle, Pan, Hao, Caballero, Sergio, Hochhaus, Guenther, Afzal, Aqeela, Jurczyk, Simona, Grant, Maria B, Edelhauser, Henry, Miller, Rehae C, Shapiro, Gideon   +13 more
core   +1 more source

Early Versus Late Recurrence in Olfactory Neuroblastoma: A Multi‐Institutional Analysis of Predictive Risk Factors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory neuroblastoma (ONB) exhibits variable recurrence patterns, with significant late recurrences occurring years after treatment. We investigated cutoff periods to define late recurrence and identified predictors that distinguish patients at risk of late recurrence from those considered cured.
Alexandria Harris, Anthony Tang, Nicholas Fung, Joao Paulo Almeida, Pierre‐Olivier Champagne, Juan Fernandez‐Miranda, Paul A. Gardner, Peter Hwang, Aristotelis Kalyvas, Chirag Patel, Zara M. Patel, Maria Peris Celda, Carlos D. Pinheiro‐Neto, Olabisi Sanusi, Carl H. Snyderman, Brian D. Thorp, Jamie J. Van Gompel, Georgios Zenonos, Nathan T. Zwagerman, Diana Bell, Edward C. Kuan, Eric W. Wang, Mathew Geltzeiler, Garret Choby   +23 more
wiley   +1 more source

PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference

, 2011
Somatostatin-based radiolabeled peptides have been successfully introduced into the clinic for targeted imaging and radionuclide therapy of somatostatin receptor (sst)-positive tumors, especially of subtype 2 (sst2).
Keelara Abiraj, Mansi, Rosalba, Cescato, Renzo, Melpomeni Fani, Wolfgang A. Weber, Tamma, Maria Luisa, Waser, Beatrice, Helmut R. Maecke, Maecke, Helmut R, Reubi, Jean-Claude, Maria Luisa Tamma, Del Pozzo, Luigi, Luigi Del Pozzo, Rosalba Mansi, Fani, Melpomeni, Abiraj, Keelara, Beatrice Waser, Renzo Cescato, Jean Claude Reubi, Weber, Wolfgang A   +19 more
core   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Contemporary nuclear medicine diagnostics of neuroendocrine tumors [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor
Todorović-Tirnanić Mila, Artiko Vera, Pavlović Smiljana, Šobić-Šaranović Dragana, Obradović Vladimir   +4 more
doaj   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Comparative evaluation for small molecule somatostatin 4 receptor agonists: in silico, in vitro, and in vivo approaches

Frontiers in Pharmacology
IntroductionThe treatment of neuropathic pain with traditional and adjuvant analgesics is limited in efficacy and associated with severe adverse effects.
Dóra Biskup, Minjin Ganbold, Andrea Kinga Nehr-Majoros, Andrea Kinga Nehr-Majoros, Andrea Kinga Nehr-Majoros, Valéria Tékus, Valéria Tékus, Valéria Tékus, Valéria Tékus, Zsófia Hajna, Zsófia Hajna, Zsófia Hajna, Barbara Fülöp, Barbara Fülöp, Éva Szőke, Éva Szőke, Éva Szőke, Éva Szőke, Éva Szőke, Csaba Hetényi, Csaba Hetényi, A. Michael Crider, Iman Daryaei, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Rita Börzsei, Rita Börzsei, Erika Pintér, Erika Pintér, Erika Pintér, Erika Pintér, Erika Pintér, Erika Pintér   +36 more
doaj   +1 more source