Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity [PDF]
eLife, 2022 Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo +8 more
doaj +3 more sources
Histopathological Evaluation of Somatostatin Receptor 2 Expression in Myocarditis—Rationale for the Diagnostic Use of Somatostatin Receptor Imaging [PDF]
DiagnosticsBackground/Objectives: Myocarditis is an inflammatory disease of the myocardium and remains to this day a challenging diagnosis. A promising novel imaging method uses the expression of somatostatin receptors (SSTRs) on inflammatory cells to visualize ...
Christian L. Polte +10 more
doaj +3 more sources
Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes [PDF]
Frontiers in Pharmacology, 2023 Glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses.
Emily G. Hoffman +3 more
doaj +2 more sources
Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells. [PDF]
PLoS ONE, 2020 Somatostatin analogs, which are used to treat neuroendocrine tumors, inhibit hormone secretion or promote tumor shrinkage; however, their efficacy varies between patients, possibly because of differential expression of somatostatin receptors (SSTRs) in ...
HanHee Jo +8 more
doaj +2 more sources
Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors [PDF]
Scientific ReportsSomatostatin analogues have recently been used as therapeutic targets for metastatic or surgically unresectable gastroenteropancreatic (GEP) neuroendocrine tumors (NETs), and associated somatostatin receptor (SSTR) expression has been well demonstrated ...
Joo Young Kim +8 more
doaj +2 more sources
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy [PDF]
Nature Communications, 2021 Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in ...
Matt Lechner +71 more
doaj +2 more sources
Somatostatin Receptor 2: A Potential Predictive Biomarker for Immune Checkpoint Inhibitor Treatment. [PDF]
Pathol Oncol Res, 2022 Wang A +6 more
europepmc +2 more sources
Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas [PDF]
Clinical and Translational MedicineYvonne Power +18 more
doaj +2 more sources
Somatostatin Receptor 2 Overexpression in Hepatocellular Carcinoma: Implications for Cancer Biology and Therapeutic Applications. [PDF]
Curr OncolHernandez Vargas S +10 more
europepmc +3 more sources
Aberrant Methylation of Somatostatin Receptor 2 Gene Is Initiated in Aged Gastric Mucosa Infected with Helicobacter pylori and Consequential Gene Silencing Is Associated with Establishment of Inflammatory Microenvironment In Vitro Study. [PDF]
Cancers (Basel), 2022 Kim HJ +12 more
europepmc +3 more sources