Results 131 to 140 of about 168,426 (311)

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder

Nature Communications, 2017
Endoderm enhancer MACS1 of Sonic Hedgehog is conserved in animals with lungs. Here, the authors show that mouse without MACS1 has defective laryngeal development, and use phylogenetic analyses to show association of evolutionary lung-gas bladder ...
Tomoko Sagai, Takanori Amano, Akiteru Maeno, Tetsuaki Kimura, Masatoshi Nakamoto, Yusuke Takehana, Kiyoshi Naruse, Norihiro Okada, Hiroshi Kiyonari, Toshihiko Shiroishi   +9 more
doaj   +1 more source

Sonic hedgehog signaling during digit pattern duplication after application of recombinant protein and expressing cells [PDF]

, 1999
Naoyuki Wada, Yasuhiko Kawakami, Tsutomu Nohno   +2 more
openalex   +1 more source

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Nature, 2020
Sebastian M. Waszak, G. Robinson, Brian L. Gudenas, Kyle S. Smith, Antoine Forget, Marija Kojic, Jesús García-López, Jennifer L. Hadley, Kayla V Hamilton, É. Indersie, I. Buchhalter, Jules N. A. Kerssemakers, N. Jäger, Tanvi Sharma, T. Rausch, M. Kool, D. Sturm, David T. W. Jones, A. Vasilyeva, R. Tatevossian, G. Neale, Bérangère Lombard, D. Loew, J. Nakitandwe, Michael C. Rusch, D. Bowers, A. Bendel, S. Partap, M. Chintagumpala, J. Crawford, N. Gottardo, Amy A. Smith, C. Dufour, S. Rutkowski, T. Eggen, F. Wesenberg, K. Kjaerheim, M. Feychting, B. Lannering, J. Schüz, C. Johansen, T. V. Andersen, M. Röösli, C. Kuehni, M. Grotzer, M. Remke, S. Puget, K. Pajtler, T. Milde, O. Witt, M. Ryzhova, A. Korshunov, B. Orr, D. Ellison, L. Brugières, P. Lichter, K. Nichols, A. Gajjar, B. Wainwright, O. Ayrault, J. Korbel, P. Northcott, S. Pfister   +62 more
semanticscholar   +1 more source

Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway

OncoTarget, 2017
Genipin, a major component of Gardenia jasminoides Ellis fruit, has been shown to inhibit the growth of gastric, prostate, and breast cancers. However, the anti-proliferative activity of genipin in colorectal cancer (CRC) has not been characterized ...
Bo Ram Kim, Y. Jeong, Y. Na, Seong Hye Park, M. Jo, Jung lim Kim, Soyeon Jeong, Suk-Young Lee, H. Kim, S. Oh, D. Lee   +10 more
semanticscholar   +1 more source

Kdf1 Regulates Molar Cusp Morphogenesis via the PI3K/AKT/mTOR Signalling Axis

Cell Proliferation, EarlyView.
Epithelial Kdf1 knockout disrupts molar cusp morphogenesis by promoting inner enamel epithelium proliferation and invagination via PI3K/AKT/mTOR signalling. ABSTRACT Keratinocyte differentiation factor 1 (Kdf1) reportedly plays a significant role in enamel formation.
Jiayu Wang, Miao Yu, Hangbo Liu, Kai Sun, Chenxin Geng, Haochen Liu, Hailan Feng, Yang Liu, Hu Zhao, Dong Han   +9 more
wiley   +1 more source

The Suppression of Medulloblastoma Cell Migration Using Clinically Significant Doses of Simvastatin through Mevalonate Pathway Targeting

Proceedings
Aims: Medulloblastoma (MBs), the most prevalent malignant paediatric brain tumour, exhibits distinct subgroups—Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4)—and each is characterized by unique molecular signatures and clinical ...
Charley Comer, Maria Victoria Niklison-Chirou   +1 more
doaj   +1 more source

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly [PDF]

, 1999
Luisa Nanni, Jeffrey E. Ming, Maureen Bocian, Kathryn A. Steinhaus, Diana W. Bianchi, Christine de Die‐Smulders, Aldo Giannotti, K Imaizumi, Kenneth Lyons Jones, Miguel Del Campo, R. A. Martin, P. Meinecke, Mary Ella Pierpont, Nathaniel H. Robin, I.D. Young, Erich Roessler, Maximilian Muenke   +16 more
openalex   +1 more source

Sonic hedgehog signaling in the lung. From development to disease.

American Journal of Respiratory Cell and Molecular Biology, 2015
Over the past two decades, the secreted protein sonic hedgehog (SHH) has emerged as a critical morphogen during embryonic lung development, regulating the interaction between epithelial and mesenchymal cell populations in the airway and alveolar ...
M. Kugler, A. Joyner, C. Loomis, J. Munger   +3 more
semanticscholar   +1 more source

Genetic Mapping of Orofacial Traits Reveals a Single Genomic Region Associated With Differences in Multiple Parameters of Jaw Size Between Astyanax mexicanus Surface and Cavefish

Evolution &Development, EarlyView.
By performing a genetic association study in cave × surface fish F2 hybrids, we discovered that premaxilla width, dentary length, and maxillary length are all significantly associated with a region on Chromosome 13 containing 109 genes. ABSTRACT The regulation of bone size is a poorly understood and complex developmental process.
Amanda K. Powers, Alleigh Amaismeier, Kathryn Thiel, William Anyonge, Suzanne E. McGaugh, Tyler E. Boggs, Clifford J. Tabin, Joshua B. Gross   +7 more
wiley   +1 more source