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Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway. [PDF]

Open Life Sci
Chen HY, Huang JM, Zheng P, Yang GX, Qin BB, Zang MX, Wang J, Li XB.   +7 more
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Expression of Sonic hedgehog (SHH) signaling molecules in ameloblastomas

Journal of Oral Pathology and Medicine, 2004
Background:  To clarify the roles of Sonic hedgehog (SHH) signal transduction in oncogenesis and cytodifferentiation of odontogenic tumors, expression of SHH, Patched (PTC), Smoothened (SMO), and GLI1 was analyzed in ameloblastomas as well as in tooth germs.Methods:  Tissue specimens of 9 tooth germs, 36 benign ameloblastomas, and 1 malignant ...
Hiroyuki Kumamoto, Kousuke Ohki, Kiyoshi Ooya   +2 more
exaly   +3 more sources

Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis

Current Urology Reports, 2016
Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is uncertain.
Walid A Farhat, Farhat Walid A
exaly   +3 more sources

Expression of Sonic hedgehog (SHH) and CDX2 in the columnar epithelium of the lower oesophagus

Digestive and Liver Disease, 2011
Decreases in Sonic hedgehog (SHH) and CDX2 expression are associated with atrophy and intestinal metaplasia in the gastric mucosa. The pathogenesis of development of Barrett's oesophagus is still unclear.To examine the gene expression of CDX2 and SHH and their signalling pathways in the columnar epithelium and the association with endoscopic appearance,
Yoshinori Fujimura, Manabu Ishii, Minoru Fujita   +2 more
exaly   +3 more sources

Duplication of 7q36.3 encompassing the Sonic Hedgehog (SHH) gene is associated with congenital muscular hypertrophy

European Journal of Medical Genetics, 2012
Muscular hypertrophy is a very rare finding on foetal ultrasonography. We present a case with recurrent muscular hypertrophy, liver enlargement and polyhydramnios in two pregnancies. One pregnancy was terminated due to suspicion of a storage disease, whereas the other led to delivery of a boy with muscular hypertrophy and mildly retarded psychomotor ...
Kroeldrup, L, Kjaergaard, S, Kirchhoff, Eva Maria, Kock, Kirsten Friis, Brasch-Andersen, Charlotte, Kibaek, M, Ousager, Lilian Bomme   +6 more
core   +5 more sources

Sonic hedgehog (SHH) mutation in patients within the spectrum of holoprosencephaly

Brain and Development, 2010
Holoprosencephaly (HPE) is a malformation sequence where the cerebral hemispheres fail to separate into distinct left and right halves. It can be associated with midline structural anomalies of the central nervous system and/or face. SHH is the major gene implicated in HPE and it plays a critical role in early forebrain and central nervous system ...
Pereira Bertolacini, Claudia Danielli, Richieri-Costa, Antonio, Ribeiro-Bicudo, Lucilene Arilho   +2 more
openaire   +3 more sources

Sonic Hedgehog (shh) expression in developing and regenerating axolotl limbs

Journal of Experimental Zoology, 1999
Sonic hedgehog (shh) expression is detectable in the posterior mesenchyme of many developing vertebrate limbs. We have isolated an RT-PCR fragment from the axolotl, Ambystoma mexicanum, that has high identity to other vertebrate shh genes. We describe the localization of this transcript during development and regeneration and in response to tissue ...
M A, Torok, D M, Gardiner, J C, Izpisúa-Belmonte, S V, Bryant   +3 more
openaire   +2 more sources

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

Development, 1997
ABSTRACT Branching morphogenesis of the embryonic lung requires interactions between the epithelium and the mesenchyme. Previously, we reported that Sonic hedgehog (Shh) transcripts are present in the epithelium of the developing mouse lung, with highest levels in the terminal buds. Here, we report that transcripts of mouse patched (Ptc),
S, Bellusci, Y, Furuta, M G, Rush, R, Henderson, G, Winnier, B L, Hogan   +5 more
openaire   +2 more sources

Phylogenetic conservation of a limb-specific, cis -acting regulator of Sonic hedgehog ( Shh )

Mammalian Genome, 2004
Polarized expression of the Sonic hedgehog ( Shh) gene in the posterior mesenchyme is essential for pattern formation in the appendages of higher vertebrates, from teleost fins to tetrapod limb buds. We report on a sequence in intron 5 of the Lmbr1 gene, which resides approximately 1 Mb from the Shh coding region in the mouse genome and is highly ...
Tomoko, Sagai, Hiroshi, Masuya, Masaru, Tamura, Kunihiko, Shimizu, Yukari, Yada, Shigeharu, Wakana, Yoichi, Gondo, Tetsuo, Noda, Toshihiko, Shiroishi   +8 more
openaire   +2 more sources