Results 71 to 80 of about 2,350,497 (231)

5-Aminolevulinic Acid Triggered by Ultrasound Halts Tumor Proliferation in a Syngeneic Model of Breast Cancer

Pharmaceuticals, 2021
Sonodynamic therapy is a bimodal therapeutic approach in which a chemical compound and ultrasound (US) synergistically act to elicit oxidative damage, triggering cancer cell death.
Federica Foglietta, Giulia Gola, Elena Biasibetti, Maria Teresa Capucchio, Iside Bruni, Andrea Francovich, Gianni Durando, Loredana Serpe, Roberto Canaparo   +8 more
doaj   +1 more source

Sonodynamic therapy

, 2010
The term sonodynamic therapy (SDT) can be described as a treatment that combines an ultrasound source with a sonosensitizing agent (a drug that can be potentiated by ultrasound) to destroy cancer cells.
Kondo, Takashi, Campbell, Paul A., Tachibana, Katsuro, Feril, Loreto B.   +3 more
core   +2 more sources

Investigation into the Sonodynamic Activity of Three Newly Synthesized Derivatives of Ciprofloxacin

Molecules
Sonosensitizers play a crucial role in the efficacy of sonodynamic antitumor therapy (SDT) and sonodynamic antimicrobial chemotherapy (SACT), highlighting the necessity for the development of new compounds with good sonodynamic activity.
Ying Zheng, Jing Lv, Jun Zhang, Yu Liu, Xiaofang Wang, Bin Liu   +5 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

, 2023
Two-dimensional (2D) metal-organic framework (MOF) nanosheets have been widely explored in recent years as diagnostic and therapeutic reagents for cancer therapies, including photodynamic therapy, chemodynamic therapy, radiation therapy, and catalytic ...
Yu, Shilong, Ma, Lufang, Zhao, Meiting, Wang, Tao, Liu, Shuyan, Hu, Tingting, Cheng, Chunhua, Li, Hai, Zhou, Zhan, Liang, Ruizheng, Tan, Chaoliang   +10 more
core   +1 more source

Stimuli-responsive nanoplatforms for sonodynamic immunotherapy: opportunities and challenges in cancer treatment

Frontiers in Immunology
Stimulus-responsive sonodynamic immunotherapy is a promising non-invasive strategy that combines ultrasound-activated Sonodynamic therapy (SDT) with a smart stimulus-responsive nanodelivery system to overcome the limitations of traditional cancer ...
Chunyu Zhang, Shu Bu, Xiaoyu Wang, Xin Shen, Yang Du, Jiangnan Yang, Zhiwei Miao   +6 more
doaj   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Using C-doped TiO₂ Nanoparticles as a Novel Sonosensitizer for Cancer Treatment

Antioxidants, 2020
Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with higher penetration ultrasound and inducing the free radicals.
Chun-Chen Yang, Chong-Xuan Wang, Che-Yung Kuan, Chih-Ying Chi, Ching-Yun Chen, Yu-Ying Lin, Gin-Shin Chen, Chun-Han Hou, Feng-Huei Lin   +8 more
doaj   +1 more source