Results 61 to 70 of about 3,188 (200)

Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy

Inorganics
As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound and sonosensitizers ...
Guiyun Wang, Yanxia Qi, Zhuang Liu, Ruowei Wang   +3 more
doaj   +1 more source

Development and optimisation of in vitro sonodynamic therapy for glioblastoma [PDF]

, 2023
Sonodynamic therapy (SDT) is currently on critical path for glioblastoma therapeutics. SDT is a non-invasive approach utilising focused ultrasound to activate photosensitisers like 5-ALA to impede tumour growth.
Banerjee, Sourav, Gao, Zifan, Hossain-Ibrahim, Kismet, Hu, Hong, Huang, Zhihong, Joseph, James, Keenlyside, Andrew, Landgraf, Lisa, Li, Han, Marples, Theodore, Melzer, Andreas, Nicely, Lynden Guy, Nogales, Joaquina, Solth, Anna   +13 more
core   +2 more sources

Immunosuppressive Microenvironment Reprogramming by Synergistic Sonodynamic Therapy of Phthalocyanine‐MOF Hybrids for Hepatocellular Carcinoma

Exploration, EarlyView.
Hepatocellular carcinoma presents a formidable clinical challenge, constructing a hypoxic and immunosuppressive microenvironment that renders conventional therapies largely ineffective. In response, we have developed Pc@Zr‐MOF, a phthalocyanine‐integrated metal‐organic framework hybrid engineered to penetrate this defensive barrier.
Han Wu, Lihui Gu, Jiahao Xu, Chuyue Zhang, Mingda Wang, Chao Li, Lanqing Yao, Yongkang Diao, Yuchen Li, Fujie Chen, Huixuan Fan, Yuze Zhao, Feng Shen, Tian Yang   +13 more
wiley   +1 more source

Nanomaterials-based precision sonodynamic therapy enhancing immune checkpoint blockade: A promising strategy targeting solid tumor

Materials Today Bio, 2023
Burgeoning is an evolution from conventional photodynamic therapy (PDT). Thus, sonodynamic therapy (SDT) regulated by nanoparticles (NPs) possesses multiple advantages, including stronger penetration ability, better biological safety, and not reactive ...
Xinlun Dai, Yangyang Du, Yumei Li, Fei Yan   +3 more
doaj   +1 more source

Hematoporphyrin monomethyl ether sonodynamic therapy (HMME-SDT) mitigates keloid scarring via the PI3K-AKT signaling pathway

Photodiagnosis and Photodynamic Therapy
This study investigates the effects and underlying molecular mechanisms of Hematoporphyrin Monomethyl Ether Sonodynamic Therapy (HMME-SDT) on keloid fibroblasts (KFs) in vitro and in vivo, utilizing animal models.The activation effect of ultrasound on HMME was ascertained using UV-visible light absorption spectroscopy.
Jingting Zhao, Zhiyi Xu, Min Li, Xiaoyu Zhai, Siqi Shen, Jing Wang, Zhinan Shi, Li Gu, Shu Zhou, Liqun Gu, Lin Chen, Bingrong Zhou, Hui Hua   +12 more
openaire   +3 more sources

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

Aggregate
Tumor drug resistance has been reported to be associated with drug efflux in tumor cells. Recently, a noninvasive and safe mechanism, sonodynamic therapy (SDT), has been proposed to be an oxidative stress strategy to potentially overcome drug efflux, but
Zhuoran Gong, Deshang Hou, Yunxue Xu, Mengxuan Wang, Shiyin Lin, Yingjuan Zheng, Zhifei Dai   +6 more
doaj   +1 more source

Update of Photodynamic Therapy and Sonodynamic Therapy in Treating Rheumatoid Arthritis [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Rheumatoid arthritis (RA) stands as a prevalent chronic autoimmune condition globally. Although conventional disease-modifying antirheumatic drugs (DMARDs) offer relief from systemic inflammation, they frequently entail undesirable side effects ...
Zhao Chenyang, Sun Desheng, Tan Li, Chen Xiangmei
doaj   +1 more source

Functional Evaluation of TiO_2 Nanoparticles-Incorporated Polyion Complex Micelles for Sonodynamic Therapy [PDF]

, 2018
Osaka Prefecture University (大阪府立大学)博士（工学）application/pdf学位記番号：論工第1522号, 指導教員：八木　繁幸doctoral ...
山本, 聡
core   +1 more source

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source