Results 41 to 50 of about 2,643 (179)

Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.
Microbubbles have been originally designed for diagnostic applications. Over the years, microbubbles and phase shift microbubbles have been further developed for therapeutic indications. ABSTRACT Ultrasound is widely used for diagnostic imaging and therapy.
Emmanuelle J. Meuillet, Evan C. Unger
wiley   +1 more source

Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles

Nanomaterials, 2023
In this study, we developed an efficient mRNA delivery vehicle by optimizing a lyophilization method for preserving human serum albumin-based nanobubbles (HSA-NBs), bypassing the need for artificial stabilizers. The morphology of the lyophilized material
Hiroshi Kida, Yutaro Yamasaki, Loreto B. Feril Jr., Hitomi Endo, Keiji Itaka, Katsuro Tachibana   +5 more
doaj   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Advances in sonoporation strategies for cancer

Frontiers in Bioscience, 2012
We will focus on the therapeutic applications of ultrasound (US) for gene transfection or 'sonoporation'. Sonoporation therapy or 'sonotherapy' is an emerging physical method for delivering drugs and/or nucleic acids for treating cancer. Because of its non-invasive nature, sonotherapy has the potential to be competitive with other treatment delivery ...
Olga, Zolochevska, Marxa L, Figueiredo
openaire   +2 more sources

Spatiotemporally controlled single cell sonoporation [PDF]

Proceedings of the National Academy of Sciences, 2012
This paper presents unique approaches to enable control and quantification of ultrasound-mediated cell membrane disruption, or sonoporation, at the single-cell level. Ultrasound excitation of microbubbles that were targeted to the plasma membrane of HEK-293 cells generated spatially and temporally controlled membrane disruption with high repeatability.
Zhenzhen, Fan, Haiyan, Liu, Michael, Mayer, Cheri X, Deng   +3 more
openaire   +2 more sources

Nanoparticles in Vascular Dementia: Advantages and Challenges

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu, JiaLi Hu, Yueming qiu, Huaying Wang, Chunxiao Shen, Ziying Liu, Yiting He, Xuefei Du, Xiaorong Zhang   +8 more
wiley   +1 more source

Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

Pharmaceutics, 2019
Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption that pore formation in the cell
Ragnhild Haugse, Anika Langer, Stein-Erik Gullaksen, Silje Maria Sundøy, Bjørn Tore Gjertsen, Spiros Kotopoulis, Emmet McCormack   +6 more
doaj   +1 more source

Progress and Challenges in Faba Bean Genetic Engineering

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Legumes are essential for global food security, serving as a vital source of plant‐based protein and playing a significant role in sustainable agricultural practices. Among legumes, faba bean (Vicia faba L.) is noteworthy due to its high‐protein content, broad climate adaptation, and suitability for cultivation in temperate regions.
Simone A. Gierlich, Thilani B. Jayakody, Sruthy Maria Augustine, Huijun Liu, Marko Jääskeläinen, Triin Vaisalu, Rod. J. Snowdon, Stig U. Andersen   +7 more
wiley   +1 more source

Sonochemotherapy: From bench to bedside

Frontiers in Pharmacology, 2015
The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects.
Bart eLammertink, Clemens eBos, Roel eDeckers, Gert eStorm, Gert eStorm, Chrit eMoonen, Jean-Michel eEscoffre   +6 more
doaj   +1 more source

Nanobubble Mediated Gene Delivery in Conjunction With a Hand-Held Ultrasound Scanner

Frontiers in Pharmacology, 2020
Recent research has revealed that nanobubbles (NBs) can be an effective tool for gene transfection in conjunction with therapeutic ultrasound (US). However, an approach to apply commercially available hand-held diagnostic US scanners for this purpose has
Hiroshi Kida, Koyo Nishimura, Koki Ogawa, Akiko Watanabe, Loreto B. Feril, Yutaka Irie, Hitomi Endo, Shigeru Kawakami, Katsuro Tachibana   +8 more
doaj   +1 more source