Results 21 to 30 of about 2,643 (179)

Sonoporation generates downstream cellular impact after membrane resealing

Scientific Reports, 2021
Sonoporation via microbubble-mediated ultrasound exposure has shown potential in drug and gene delivery. However, there is a general lack of mechanistic knowledge on sonoporation-induced cellular impact after membrane resealing, and this issue has made ...
Xinxing Duan, Qian Zhou, Jennifer M. F. Wan, Alfred C. H. Yu   +3 more
doaj   +1 more source

Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys

Pharmaceutics, 2021
The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path also pass through healthy tissues.
Oystein Eikrem, Spiros Kotopoulis, Mihaela Popa, Mireia Mayoral Safont, Kjell Ove Fossan, Sabine Leh, Lea Landolt, Janka Babickova, Oddrun Anita Gudbrandsen, Odd Helge Gilja, Bettina Riedel, Jan Schjøtt, Emmet McCormack, Hans-Peter Marti   +13 more
doaj   +1 more source

Advances in BBB on Chip and Application for Studying Reversible Opening of Blood–Brain Barrier by Sonoporation

Micromachines, 2022
The complex structure of the blood–brain barrier (BBB), which blocks nearly all large biomolecules, hinders drug delivery to the brain and drug assessment, thus decelerating drug development.
Yicong Cai, Kexin Fan, Jiawei Lin, Lin Ma, Fenfang Li   +4 more
doaj   +1 more source

Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells

Pharmaceutics, 2020
The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy.
Ragnhild Haugse, Anika Langer, Elisa Thodesen Murvold, Daniela Elena Costea, Bjørn Tore Gjertsen, Odd Helge Gilja, Spiros Kotopoulis, Gorka Ruiz de Garibay, Emmet McCormack   +8 more
doaj   +1 more source

SonoVue^® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?

Pharmaceutics, 2022
The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has shown great promise in cancer therapy from in vitro to ongoing clinical studies.
Spiros Kotopoulis, Mihaela Popa, Mireia Mayoral Safont, Elisa Murvold, Ragnhild Haugse, Anika Langer, Georg Dimcevski, Christina Lam, Tormod Bjånes, Odd Helge Gilja, Emmet Mc Cormack   +10 more
doaj   +1 more source

Microbubble–Nanoparticle Complexes for Ultrasound-Enhanced Cargo Delivery

Pharmaceutics, 2022
Targeted delivery of therapeutics to specific tissues is critically important for reducing systemic toxicity and optimizing therapeutic efficacy, especially in the case of cytotoxic drugs.
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt   +2 more
doaj   +1 more source

Application of Direct Sonoporation from a Defined Surface Area of the Peritoneum: Evaluation of Transfection Characteristics in Mice

Pharmaceutics, 2019
In the present study, we developed a sonoporation system, namely “direct sonoporation”, for transfecting the peritoneum from a defined surface area to avoid systematic side effects. Here, the transfection characteristics are explained because
Koyo Nishimura, Keita Yonezawa, Shintaro Fumoto, Yusuke Miura, Masayori Hagimori, Koyo Nishida, Shigeru Kawakami   +6 more
doaj   +1 more source

The Assessment of Calcium and Bleomycin Cytotoxic Efficiency in Relation to Cavitation Dosimetry

Pharmaceutics, 2023
Microbubble (MB)- and ultrasound (US)-facilitated intracellular Ca2+ delivery, known as sonoporation (SP), is a promising anticancer treatment modality, since it allows a spatio-temporally controllable and side-effect-free alternative to conventional ...
Martynas Maciulevičius, Renaldas Raišutis, Baltramiejus Jakštys, Linas Svilainis, Andrius Chaziachmetovas, Saulius Šatkauskas   +5 more
doaj   +1 more source

Spatial and Temporal Control of Cavitation Allows High In Vitro Transfection Efficiency in the Absence of Transfection Reagents or Contrast Agents.

PLoS ONE, 2015
Sonoporation using low-frequency high-pressure ultrasound (US) is a non-viral approach for in vitro and in vivo gene delivery. In this study, we developed a new sonoporation device designed for spatial and temporal control of ultrasound cavitation.
Kamel Chettab, Stéphanie Roux, Doriane Mathé, Emeline Cros-Perrial, Maxime Lafond, Cyril Lafon, Charles Dumontet, Jean-Louis Mestas   +7 more
doaj   +1 more source

Sonoporation from Jetting Cavitation Bubbles [PDF]

Biophysical Journal, 2006
The fluid dynamic interaction of cavitation bubbles with adherent cells on a substrate is experimentally investigated. We find that the nonspherical collapse of bubbles near to the boundary is responsible for cell detachment. High-speed photography reveals that a wall bounded flow leads to the detachment of cells. Cells at the edge of the circular area
Ohl, C.D., Arora, M., Ikink, Roy, de Jong, N., Versluis, Michel, Delius, Michael, Lohse, Detlef   +6 more
openaire   +4 more sources