Results 11 to 20 of about 2,643 (179)
Ultrasonics Sonochemistry, 2023 As a non-viral transfection method, ultrasound and microbubble-induced sonoporation can achieve spatially targeted gene delivery with synergistic immunostimulatory effects.
Yuanchao Shi +6 more
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Epidermal growth factor receptor-targeted sonoporation with microbubbles enhances therapeutic efficacy in a squamous cell carcinoma model. [PDF]
PLoS ONE, 2017 Sonoporation is a drug and gene delivery system using ultrasonication that allows the intracellular delivery of foreign molecules that cannot enter cells under normal conditions.
Fumika Hirabayashi +9 more
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Pharmaceutics, 2021 Gene therapy is expected to be used for the treatment of peritoneal fibrosis, which is a serious problem associated with long-term peritoneal dialysis. Hepatocyte growth factor (HGF) is a well-known anti-fibrotic gene.
Koyo Nishimura +5 more
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Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors
BME Frontiers, 2022 Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation, is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living cells.
Juan Tu, Alfred C. H. Yu
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Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation
BIO Integration, 2021 Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and ...
Yue Li, Zhiyi Chen, Shuping Ge
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Sudden Cell Death Induced by Ca2+ Delivery via Microbubble Cavitation
Biomedicines, 2021 Intracellular calcium ion delivery via sonoporation has been validated to be a substitute for classical chemotherapy. However, the mechanism behind calcium sonoporation remains unclear to this day.
Martynas Maciulevičius +4 more
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Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells
Pharmaceutics, 2020 Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles to increase the permeability
Tormod Bjånes +8 more
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Non-Cavitation Targeted Microbubble-Mediated Single-Cell Sonoporation
Micromachines, 2022 Sonoporation employs ultrasound accompanied by microbubble (MB) cavitation to induce the reversible disruption of cell membranes and has been exploited as a promising intracellular macromolecular delivery strategy.
Xiufang Liu +8 more
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Sonoporation at a low mechanical index [PDF]
Bubble Science, Engineering & Technology, 2011 AbstractThe purpose of this study was to investigate the physical mechanisms of sonoporation, in order to understand and improve ultrasound-assisted drug and gene delivery. Sonoporation is the transient permeabilisation and resealing of a cell membrane with the help of ultrasound and/or an ultrasound contrast agent, allowing for the trans-membrane ...
Delalande, Anthony +4 more
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Different effects of sonoporation on cell morphology and viability
Biomolecules & Biomedicine, 2012 The objective of our study was to investigate changes in cell morphology and viability after sonoporation. Sonoportion was achieved by ultrasound (21 kHz) exposure on adherent human prostate cancer DU145 cells in the cell culture dishes with the ...
Ji-Zhen Zhang +3 more
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