Biophysical insight into mechanisms of sonoporation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Gas-filled microbubbles physically oscillate in an ultrasound field and have been shown to potentiate the delivery of therapeutic payloads. The biophysical mechanisms by which vibrating microbubbles stimulate macromolecule uptake across the cell membrane, however, remain unknown.
Xucai Chen +2 more
exaly +3 more sources
Sonoporation with Echogenic Liposomes: The Evaluation of Glioblastoma Applicability Using In Vivo Xenograft Models. [PDF]
PharmaceuticsObjective: In previous studies, echogenic liposomes with liquid and gas cores were analyzed as alternative carriers of drug molecules and cavitation nuclei for sonoporation.
Park JH +6 more
europepmc +2 more sources
Key factors that affect sonoporation efficiency in in vitro settings: The importance of standing wave in sonoporation [PDF]
Biochemical and Biophysical Research Communications, 2007 Ultrasound-induced intracellular drug delivery, sonoporation, is an appealing and promising technique for next generation drug delivery system. Many types of molecules, such as plasmid DNAs, siRNAs and peptides, have been demonstrated to be delivered into the cell by ultrasound with the aid of microbubbles both in vitro and in vivo.
Kullervo Hynynen, Manabu Kinoshita
exaly +3 more sources
Influence of cell shape on sonoporation efficiency in microbubble-facilitated delivery using micropatterned cell arrays. [PDF]
Sci RepMicrobubble-facilitated sonoporation is a rapid, versatile, and non-viral intracellular delivery technique with potential for clinical and ex vivo cell engineering applications.
Baig MA, Du Y, Zan Z, Fan Z.
europepmc +2 more sources
Sonoporation of Cells by a Parallel Stable Cavitation Microbubble Array
Advanced Science, 2019 Sonoporation is a targeted drug delivery technique that employs cavitation microbubbles to generate transient pores in the cell membrane, allowing foreign substances to enter cells by passing through the pores.
Long Meng, Lisheng Xu, Feiyan Cai
exaly +2 more sources
Dynamic reorganization of multivesicular bodies and exosome production impacted by sonoporation. [PDF]
Sci RepNaturally occurring cell-derived extracellular vesicles (EVs) have emerged as attractive nanocarriers for drug delivery. However, production of large quantities of EVs for clinical applications in a scalable manner remains a significant challenge.
Li W +6 more
europepmc +2 more sources
The molecular impact of sonoporation: A transcriptomic analysis of gene regulation profile. [PDF]
Ultrason SonochemSonoporation has long been known to disrupt intracellular signaling, yet the involved molecules and pathways have not been identified with clarity.
Duan X, Wan JMF, Yu ACH.
europepmc +2 more sources
Ultrasound medicine in the era of precision theranostics: Mechanisms, molecular strategies, and clinical translation. [PDF]
Iran J Basic Med SciUltrasound (US) has evolved from a solely diagnostic tool into a multifaceted theranostics platform, proficient in both high-resolution imaging and tailored therapeutic intervention.
Wang L, Luo Z, Liu D.
europepmc +2 more sources
Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study
Pharmaceutics, 2023 Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear.
Sandrine Kerneis +10 more
doaj +1 more source
Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine
Bioengineering, 2022 Research on the capability of non-viral gene delivery systems to induce tissue regeneration is a continued effort as the current use of viral vectors can present with significant limitations.
Zoe Krut +3 more
doaj +1 more source