Results 31 to 40 of about 2,643 (179)
Efficacy and Safety of Low-Intensity Pulsed Ultrasound-Induced Blood–Retinal Barrier Opening in Mice
Pharmaceutics, 2023 Systemic drugs can treat various retinal pathologies such as retinal cancers; however, their ocular diffusion may be limited by the blood–retina barrier (BRB).
Alexandre Bourdin +8 more
doaj +1 more source
The size of sonoporation pores on the cell membrane [PDF]
2008 IEEE Ultrasonics Symposium, 2008 Sonoporation uses ultrasound (US) to generate transient nonselective pores on the cell membrane and has been exploited as a nonviral intracellular drug and gene delivery strategy. The pore size determines the size of agents that can be delivered into the cytoplasm using the technique. However, measurements of the dynamic, submicron-scale pores have not
Zhou, Yun +3 more
openaire +3 more sources
Pharmaceutics, 2023 Despite recent advancements in ultrasound-mediated drug delivery and the remarkable success observed in pre-clinical studies, no delivery platform utilizing ultrasound contrast agents has yet received FDA approval.
Arvin Honari, Shashank R. Sirsi
doaj +1 more source
Synchronized Optical and Acoustic Droplet Vaporization for Effective Sonoporation
Pharmaceutics, 2019 Inertial cavitation-based sonoporation has been utilized to enhance treatment delivery efficacy. In our previous study, we demonstrated that tumor therapeutic efficacy can be enhanced through vaporization-assisted sonoporation with gold nanodroplets ...
Wei-Wen Liu, Sy-Han Huang, Pai-Chi Li
doaj +1 more source
Sonoporation delivery of monoclonal antibodies against human papillomavirus 16 E6 restores p53 expression in transformed cervical keratinocytes. [PDF]
PLoS ONE, 2012 High-risk types of human papillomavirus (HPV), such as HPV16, have been found in nearly all cases of cervical cancer. Therapies targeted at blocking the HPV16 E6 protein and its deleterious effects on the tumour suppressor pathways of the cell can ...
Melissa Togtema +5 more
doaj +1 more source
Ultrasound-Mediated Drug Delivery With a Clinical Ultrasound System: In Vitro Evaluation
Frontiers in Pharmacology, 2021 Chemotherapy efficacy is often reduced by insufficient drug uptake in tumor cells. The combination of ultrasound and microbubbles (USMB) has been shown to improve drug delivery and to enhance the efficacy of several drugs in vitro and in vivo, through ...
Josanne S. de Maar +7 more
doaj +1 more source
Advanced Science, EarlyView.We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai +9 more
wiley +1 more source
Pharmaceutics, 2021 Sonoporation is the process of cell membrane permeabilization, due to exposure to ultrasounds. There is a lack of consensus concerning the mechanisms of sonoporation: Understanding the mechanisms of sonoporation refines the choice of the ultrasonic ...
Florian N. Gailliègue +3 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou +3 more
wiley +1 more source
Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells
Pharmaceutics, 2022 In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia.
Stephanie He +3 more
doaj +1 more source