Results 121 to 130 of about 126,024 (329)

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]

, 2018
In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A., Marchetti, P., Nuti, M., Rughetti, A., Zizzari, I. G.   +4 more
core   +1 more source

Current Status of Multidisciplinary Treatment Strategies for Hepatocellular Carcinoma in the Era of Advanced Systemic Therapies

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT The therapeutic landscape of hepatocellular carcinoma (HCC) has been transformed by recent advancements in systemic therapies, particularly with the introduction of immune checkpoint inhibitors, expanding treatment options beyond conventional locoregional approaches.
Keiichi Akahoshi, Shun Kaneko, Shinji Tanaka, Minoru Tanabe, Daisuke Ban   +4 more
wiley   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core  

Years of life that could be saved from prevention of hepatocellular carcinoma [PDF]

, 2016
BACKGROUND: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved.
Affronti, A., Balsamo, Claudia, Barcellona, Maria Rosa, Baroni, Gianluca Svegliati, Benvegnu', Luisa, Bernardi, M., Biasini, Elisabetta, Biselli, Maurizio, Bolondi, Luigi, Borzio, F., Bosco, Giulia, Bucci, L., Cabibbo, Giuseppe, Camm\ue0, Calogero, Cappa, Federica Mirici, Cappelli, Alberta, Caraceni, Paolo, Caturelli, E., Chiaramonte, Maria, Ciccarese, F., Costantino, Andrea, Cucchetti, A, Dall'Aglio, Anna Chiara, Del Poggio, Paolo, Dell'Isola, Serena, Di Marco, M., Domenicali, Marco, Farinati, Fabio, Felder, M., Feletti, Valentina, Foschi, F. G., Gasbarrini, A., Gazzola, Alessia, Gemini, S., Giannini, E. G., Golfieri, Rita, Gramenzi, Annagiulia, Guarino, Maria, Lalungo, Anna Maria, Lanzi, Arianna, Magalotti, Donatella, Maida, M., Marchetti, Fabiana, Masotto, A., Mega, Andrea, Mismas, Valeria, Missale, G., Morisco, F., Moscatelli, Alessandro, Mosconi, Cristina, Murer, Francesca, Neri, Elga, Olmi, Stefano, Pecorelli, Anna, Pellegatta, Gaia, Picciotto, Antonino, Pinna, A. D., Piscaglia, F., Porro, Emanuela, Pozzan, Caterina, Rapaccini, G. L., Rastrelli, Elena, Ravaioli, M., Renzulli, Matteo, Rinninella, Emanuele, Roselli, Paola, Sacco, R., Savarino, Vincenzo, Schiad\ue0, Laura, Serra, Carla, Stefanini, Giuseppe Francesco, Tamberi, Stefano, Trevisani, F., Valerio, Matteo, Vanin, Veronica, Vavassori, Elena, Venerandi, Laura, Virdone, Roberto, Zoli, M.   +78 more
core   +1 more source

Potential Therapeutic Agents against Paclitaxel—And Sorafenib-Resistant Papillary Thyroid Carcinoma [PDF]

, 2022
Seok‐Mo Kim, Keunwan Park, Jin Hong Lim, Hyeok Jun Yun, Sang Yong Kim, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Cheol‐Ho Pan, Ki Cheong Park   +10 more
openalex   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Surgical Outcomes and Recurrence Management in Borderline Resectable Hepatocellular Carcinoma: Implications for Multidisciplinary Strategies

Annals of Gastroenterological Surgery, EarlyView.
Multivariate analysis identified that up‐to‐7 out (p < 0.001), lymph node metastasis (p < 0.001), and non‐anatomical resection (p = 0.02) were independent predictors of cancer recurrence, while older age (p = 0.01), Child‐Pugh B (p < 0.001), up‐to‐7 out (p = 0.01), macrovascular invasion (p = 0.01), and lymph node metastasis (p < 0.001) were ...
Koichiro Haruki, Kenei Furukawa, Munetoshi Akaoka, Yuto Yamahata, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Toru Ikegami   +9 more
wiley   +1 more source

Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells [PDF]

, 2017
Induction of necroptosis has emerged as an alternative approach to trigger programmed cell death, in particular in apoptosis-resistant cancer cells.
Feldmann, Friederike, Fulda, Simone, Martens, Sofie, Schenk, Barbara, Vandenabeele, Peter   +4 more
core   +3 more sources

Synthesis and Cytotoxicity Study of Magnetite Nanoparticles Coated with Polyethylene Glycol and Sorafenib–Zinc/Aluminium Layered Double Hydroxide [PDF]

, 2020
Mona Ebadi, Kalaivani Buskaran, Bullo Saifullah, Mohd Zobir Hussein, Sharida Fakurazi, Giorgia Pastorin   +5 more
openalex   +1 more source