Sorting (Nexin-13) out Novel Insights into Endolysosomal Cholesterol Export [PDF]
Contact, 2022 Transport in and out of the endolysosomal compartment represents a key step in the regulation of cellular cholesterol homeostasis. Despite important recent advances, how LDL-derived, free cholesterol is exported from the lumen of endolysosomes to other ...
Albert Lu
doaj +5 more sources
Contribution of Sorting Nexin 3 in the Cytomegalovirus Assembly [PDF]
BiomedicinesBackground/Objectives: Cytomegalovirus (CMV) infection expands early endosomes (EEs) into tubular extensions that may contribute to the control of virus replication and virion assembly.
Ivona Viduka +7 more
doaj +5 more sources
Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling [PDF]
Cell Death and DiseasePulmonary fibrosis (PF) is a chronic progressive lung disorder characterized by overactivation of Wnt/β-catenin signaling and limited therapeutic efficacy.
Dinghu Ma +12 more
doaj +4 more sources
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis [PDF]
Acta Pharmaceutica Sinica B, 2023 The clinical utilization of doxorubicin (Dox) in various malignancies is restrained by its major adverse effect: irreversible cardiomyopathy. Extensive studies have been done to explore the prevention of Dox cardiomyopathy.
Wenjing Yu +12 more
doaj +3 more sources
Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting [PDF]
JCI Insight, 2023 Glioblastoma is the most malignant primary brain tumor, the prognosis of which remains dismal even with aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity due to
Ryan C. Gimple +19 more
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Structural determinants specific for retromer protein sorting nexin 5 in regulating subcellular retrograde membrane trafficking. [PDF]
J Biomed Res, 2023 The endosomal trafficking of signaling membrane proteins, such as receptors, transporters and channels, is mediated by the retromer-mediated sorting machinery, composed of a cargo-selective vacuolar protein sorting trimer and a membrane-deforming subunit
Chen Q, Sun M, Han X, Xu H, Liu Y.
europepmc +4 more sources
The Sorting Nexin Genes ChSNX4 and ChSNX41 Are Required for Reproductive Development, Stress Adaption and Virulence in Cochliobolus heterostrophus [PDF]
Journal of Fungi, 2022 Sorting nexins are a conserved protein family involved in many cellular processes in fungi, and the function of sorting nexin Snx4 (Atg24) and Snx41 (Atg20) in Cochliobolus heterostrophus was not clear.
Huilin Yu +5 more
doaj +3 more sources
The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. [PDF]
PLoS ONE, 2018 Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde trafficking of the cation independent mannose 6-phosphate receptor (CI-M6PR) and macropinocytosis.
Nao Itai +9 more
doaj +4 more sources
Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse [PDF]
Frontiers in Immunology, 2022 Sorting nexin 27 (SNX27) association to the retromer complex mediates intracellular trafficking of cargoes containing PSD95/Dlg1/ZO-1 (PDZ)-binding C-terminal sequences from endosomes to the cell surface, preventing their lysosomal degradation.
Natalia González-Mancha +3 more
doaj +3 more sources
Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Bone homeostasis is a complex, multi-step process, which is based primarily on a tightly orchestrated interplay between bone formation and bone resorption that is executed by osteoblasts and osteoclasts (OCLs), respectively.
Ari Elson +10 more
doaj +3 more sources