Results 91 to 100 of about 545,864 (271)

Sorting nexins provide diversity for retromer-dependent trafficking events [PDF]

Nature Cell Biology, 2011
Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have fundamental roles in orchestrating cargo sorting through the membranous maze that is the endosomal network. One ancient group of complexes that contain sorting nexins is the retromer.
Peter J. Cullen, Hendrik C. Korswagen
openalex   +6 more sources

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Comprehensive analysis and validation of SNX7 as a novel biomarker for the diagnosis, prognosis, and prediction of chemotherapy and immunotherapy response in hepatocellular carcinoma

BMC Cancer, 2023
Background Studies have demonstrated that Sorting nexin 7 (SNX7) functions as an anti-apoptotic protein in liver tissue and plays a crucial role in the survival of hepatocytes during early embryonic development.
Jianlin Chen, Gan Gao, Yi Zhang, Peng Dai, Yi Huang   +4 more
doaj   +1 more source

Functional Analysis of BcSNX3 in Regulating Resistance to Turnip Mosaic Virus (TuMV) by Autophagy in Pak-choi (Brassica campestris ssp. chinensis)

Agronomy, 2022
Sorting nexin protein is a class of highly conserved eukaryotic proteins containing the PX domain. Recent studies related to SNX in plants have focused on the regulation of abiotic stress processes, and there are few studies on the involvement of SNX in ...
Rujia Zhang, Changwei Zhang, Shanwu Lyu, Zhiyuan Fang, Hongfang Zhu, Xilin Hou   +5 more
doaj   +1 more source

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50 [PDF]

, 2016
Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs
Cullen, Peter J., Dengjel, Jörn, Diedrich, Britta, Heesom, Kate J., Kvainickas, Arunas, Nägele, Heike, Orgaz, Ana Jimenez, Steinberg, Florian   +7 more
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane [PDF]

, 1995
The sorting of apical and basolateral proteins into vesicular carriers takes place in the trans-Golgi network (TGN) in MDCK cells. We have previously analyzed the protein composition of immunoisolated apical and basolateral transport vesicles and have ...
Fiedler, K., Lafont, F., Parton, R. G., Simons, K.   +3 more
core   +3 more sources

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, EarlyView.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

SNX16 is required for hepatocellular carcinoma survival via modulating the EGFR-AKT signaling pathway

Scientific Reports
Sorting nexin 16 (SNX16), a pivotal sorting nexin, emerges in tumor progression complexity, fueling research interest. However, SNX16’s biological impact and molecular underpinnings in hepatocellular carcinoma (HCC) remain elusive.
Lebin Yuan, Yanqiu Meng, Jiajia Xiang
doaj   +1 more source

The role of snx41-based pexophagy in magnaporthe development. [PDF]

PLoS ONE, 2013
Pexophagy, the degradation of peroxisomes via selective autophagy, depends on Atg20/Snx42 function in Saccharomyces cerevisiae. Besides its role in selective autophagy, Atg20/Snx42 is also involved in an autophagy-independent endosomal retrieval ...
Yizhen Deng, Ziwei Qu, Naweed I Naqvi
doaj   +1 more source