Results 111 to 120 of about 545,864 (271)

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Proteomic profiling reveals the transglutaminase-2 externalization pathway in kidneys after unilateral ureteric obstruction [PDF]

, 2018
Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion.
A., Ball, Boocock, C., C., Coveney, D., E., Furini, G., G., Huang, Johnson, L., N., R., Ramaswamy, Scarpellini, Schroeder, T.S., Tonoli, Verderio, Verderio Edwards E   +22 more
core   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Structure and Plasticity of Endophilin and Sorting Nexin 9 [PDF]

Structure, 2008
Endophilin and Sorting Nexin 9 (Snx9) play key roles in endocytosis by membrane curvature sensing and remodeling via their Bin/Amphiphysin/Rvs (BAR) domains. BAR and the related F-BAR domains form dimeric, crescent-shaped units that occur N- or C-terminally to other lipid-binding, adaptor, or catalytic modules. In crystal structures, the PX-BAR unit of
Wang, Qi, Kaan, Hung Yi Kristal, Hooda, Reshma Noordin, Goh, Shih Lin, Sondermann, Holger   +4 more
openaire   +2 more sources

Sorting Out the Role of α-Synuclein in Retromer-Mediated Endosomal Protein Sorting

Journal of Experimental Neuroscience, 2018
Retromer is a phylogenetically conserved, multisubunit coat complex that controls endosomal protein trafficking and sorting. Mutations in the retromer gene VPS35 cause late-onset Parkinson disease, suggesting that trafficking defects cause ...
Dhaval Patel, Stephan N Witt
doaj   +1 more source

AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway [PDF]

, 2012
The sorting of signaling receptors within the endocytic system is important for appropriate cellular responses. After activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosomes and degraded.
Dores, Michael R, Lin, Huilan, Marchese, Adriano, Montagne, William A, Paing, May M, Trejo, JoAnn   +5 more
core   +2 more sources

Sorting Nexin 27-dependent regulation of Lck and CD4 tunes the initial stages of T-cell activation.

Journal of Leukocyte Biology
Sorting nexin (SNX) 27 is a unique member of the SNX family of proteins that mediates the endosome-to-plasma membrane trafficking of cargos bearing a PSD95/Dlg1/ZO-1 (PDZ)-binding motif.
Cristina Rodríguez-Rodríguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Isabel Mérida   +3 more
semanticscholar   +1 more source

Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography–Tandem Mass Spectrometry

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 128-139, March 2026.
ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Aruvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang, Sirintra Sirivisoot, Tanit Kasantikul, Sittiruk Roytrakul, Narumon Phaonakrop, Nlin Arya   +7 more
wiley   +1 more source

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins [PDF]

, 2016
The retromer complex acts as a scaffold for endosomal protein complexes that sort integral membrane proteins to various cellular destinations. The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26.
Adam P. Jellett, Arighi, Balana, Bean, Bean, Brett M. Collins, Burd, Cai, Chan, Chapin, Chris M. Danson, Cullen, Damseh, Frances C. Tilley, Freeman, Gallon, Gomez, Gustavsson, Harbour, Harbour, Hesketh, Ian McGough, Joubert, Kate J. Heesom, Kerr, Kevin A. Wilkinson, Kirsty J. McMillan, Lauffer, MacLeod, Matthew Gallon, McGough, McGough, Muhammad, Peter J. Cullen, Phillips-Krawczak, Popoff, Rovelet-Lecrux, Seaman, Seaman, Seaman, Seaman, Shannon, Shi, Small, Steinberg, Steinberg, Temkin, Thomas Clairfeuille, Vardarajan, Vilariño-Güell, Vilariño-Güell, Wang, Yoshimura, Zavodszky, Zimprich   +54 more
core   +3 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source