Results 131 to 140 of about 545,864 (271)

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9‐i) primarily lower LDL‐cholesterol (LDL‐C) by blocking PCSK9‐mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearance. Beyond LDLR‐dependent effects, PCSK9‐i exert multiple benefits via LDLR‐independent pathways.
Jia Kuang, Lei Hao, Meibiao Zhang, Zhao Yang   +3 more
wiley   +1 more source

SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell

Frontiers in Cellular and Infection Microbiology, 2017
To invade epithelial cells, Salmonella enterica serovar Typhimurium (S. Typhimurium) induces macropinocytosis through the action of virulence proteins delivered across the host cell membrane via a type III secretion system.
David Liebl, Xiaying Qi, Yang Zhe, Timothy C. Barnett, Timothy C. Barnett, Rohan D. Teasdale, Rohan D. Teasdale, Rohan D. Teasdale   +7 more
doaj   +1 more source

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome. [PDF]

, 2016
Dysfunction of VAMP-associated protein (VAP) is associated with neurodegeneration, both Amyotrophic Lateral Sclerosis and Parkinson's disease. Here we summarize what is known about the intracellular interactions of VAP in humans and model organisms.
Levine, TP, Murphy, SE
core   +1 more source

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, Volume 25, Issue 21-22, Page 6-24, November 2025.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments [PDF]

, 2017
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) stretch within the Huntingtin (Htt) protein.
Akbergenova, Yulia, Littleton, J. Troy
core   +1 more source

Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo

Developmental Neurobiology, Volume 85, Issue 4, October 2025.
ABSTRACT Prenatal stress, mediated by elevated glucocorticoid (GC) levels, is a relevant modulator of fetal brain development and a known risk factor for neurodevelopmental disorders. Using the avian embryo as a vertebrate model, we injected corticosterone into the yolk on embryonic day 6 (E6) and assessed neurodevelopmental outcomes at day 14 (E14 ...
Bela Gaertner, Gabriela Morosan‐Puopolo, Beate Brand‐Saberi, Charmaine Schücke, Darius Saberi, Katharina Klöster, Simon Faissner, Katrin Marcus, Morris Gellisch, Britta Eggers   +9 more
wiley   +1 more source

Phosphatidylinositol 3,5‐bisphosphate: Low abundance, high significance [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102155/1/bies201300012 ...
Alghamdi, Augsten, Baars, Bak, Baskaran, Berger, Berwick, Bolino, Bolis, Bonangelino, Bonangelino, Botelho, Botelho, Bridges, Brockerhoff, Bryant, Burd, Cabezas, Campeau, Carlton, Carlton, Carmel, Carricaburu, Choudhury, Chow, Chow, Cooke, de Lartigue, Dong, Dove, Dove, Dove, Dove, Duex, Duex, Efe, Er, Falkenburger, Ferguson, Ferguson, Gary, Gary, Guo, Han, Hazeki, Hirano, Hirano, Ho, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Ikonomov, Jefferies, Jeffries, Jin, Jones, Katoh, Katona, Kerr, Kotoulas, Krick, Lemaire, Lemmon, Lenk, Li, Manford, Martin, Martyn, McEwen, Michell, Morishita, Narayan, Nicot, Norris, Onishi, Oppelt, Osborne, Proikas-Cezanne, Rameh, Rudge, Rusten, Rusten, Rutherford, Sbrissa, Sbrissa, Sbrissa, Sbrissa, Sbrissa, Schu, Seebohm, Shen, Shisheva, Shisheva, Silswal, Takasuga, Touchberry, Tronchere, Tsuruta, Vaccari, van Gisbergen, Wang, Watanabe, Whiteford, Whitley, Whitley, Winters, Yamamoto, Yan, Zhang, Zhang, Zhang, Zhou, Zieger, Zolov   +119 more
core   +1 more source

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI‐α and Controls Myogenic Differentiation

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Muscle RING finger (MuRF) proteins are striated muscle‐specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function.
Ning Li, Jida Hamati, Yi Li, Björn Brinschwitz, Mohamed Ghait, Elisa Martin, Dörte Lodka, Elke Hammer, Britta Fielitz, Uwe Völker, Gunnar Dittmar, Thomas Sommer, Friedrich C. Luft, Jens Fielitz   +13 more
wiley   +1 more source

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. [PDF]

, 2012
The FERM-like domain-containing sorting nexins of the SNX17/SNX27/SNX31 family have been proposed to mediate retrieval of transmembrane proteins from the lysosomal pathway.
Arighi, Bass, Burden, Carlton, Carlton, Caswell, Cullen, Cullen, Dozynkiewicz, Florian Steinberg, Ghai, Gomez, Grant, Harterink, Huss, Johannes, Jović, Kate J. Heesom, Lane, Lauffer, Lee, Li, Lobert, Margadant, Mark D. Bass, Moser, Muhammad, Peter J. Cullen, Roca-Cusachs, Salicioni, Seaman, Seet, Stockinger, Temkin, Tiwari, van Kerkhof, Wassmer, Wassmer, White, Worby, Zech   +40 more
core   +2 more sources

Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study

Genes, Brain and Behavior, Volume 24, Issue 5, October 2025.
No genome‐wide association study (GWAS) on cognitive function in individuals of Japanese ancestry has been conducted. This study performed GWASs on cognitive function in elderly Japanese individuals, identifying two significant loci on chromosomes 6 and 20 (near PRL, HDGFL1, and BANF2, SNX5).
Genki Shinoda, Taku Obara, Ippei Takahashi, Hisashi Ohseto, Chikana Kawaguchi, Akira Narita, Aoi Noda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Makiko Taira, Hiroshi Sakamoto, Naoki Nakaya, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Shunji Mugikura, Kyoko Suzuki, Shinichi Kuriyama   +18 more
wiley   +1 more source