Results 11 to 20 of about 545,864 (271)

The Role of Sorting Nexin 17 in Cardiac Development [PDF]

Frontiers in Cardiovascular Medicine, 2021
Sorting nexin 17 (SNX17), a member of sorting nexin (SNX) family, acts as a modulator for endocytic recycling of membrane proteins. Results from our previous study demonstrated the embryonic lethality of homozygous defect of SNX17.
Yufei Wu, Yaqun Zhou, Jian Huang, Ke Ma, Tianyou Yuan, Yong Jiang, Maoqing Ye, Jun Li   +7 more
doaj   +5 more sources

Sorting nexin 5 mediates virus-induced autophagy and immunity. [PDF]

Nature, 2021
Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, including immune system development, regulation of innate and adaptive immune and inflammatory responses, selective ...
Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B.   +25 more
europepmc   +7 more sources

A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning. [PDF]

Tumour Virus Res
Li S, Williamson ZL, Christofferson MA, Jeevanandam A, Campos SK.   +4 more
europepmc   +3 more sources

The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5. [PDF]

Life Sci Alliance, 2023
Binding of sorting nexin SNX5 to the VAB domain of VPS13A mediates its recruitment to membrane contact sites between SNX5-containing endosomal membranes, mitochondria, and ER. Human VPS13 proteins are implicated in severe neurological diseases.
Tornero-Écija A, Zapata-Del-Baño A, Antón-Esteban L, Vincent O, Escalante R.   +4 more
europepmc   +2 more sources

Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. [PDF]

Sci Adv, 2023
Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease. Cholesterol availability is critical for ISC stemness.
Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X.   +19 more
europepmc   +2 more sources

Sorting nexin 9 expression and prognostic implications in lung adenocarcinoma: integrative bioinformatic and <i>in vitro</i> validation. [PDF]

Transl Cancer Res
Background Sorting nexin 9 (SNX9) is involved in intracellular vesicle transport and signal transduction, and its abnormal expression is related to the occurrence and development of a variety of cancers.
Liu W, Yin Y, Wang B, Li T, Chen J.
europepmc   +2 more sources

Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor. [PDF]

Cancer Gene Ther, 2023
Overexpression and/or overactivation of the Epidermal Growth Factor Receptor (EGFR) is oncogenic in several tumor types yet targeting the kinase domain of wildtype EGFR has had limited success.
Atwell B, Chen CY, Christofferson M, Montfort WR, Schroeder J.   +4 more
europepmc   +2 more sources

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes. [PDF]

Mol Biol Cell, 2023
Proper balance of exocytosis and endocytosis is important for the maintenance of plasma membrane lipid and protein homeostasis. This is especially critical in human podocytes and the podocyte-like Drosophila nephrocytes that both use a delicate diaphragm
Maruzs T, Feil-Börcsök D, Lakatos E, Juhász G, Blastyák A, Hargitai D, Jean S, Lőrincz P, Juhász G.   +8 more
europepmc   +2 more sources

Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis. [PDF]

Cancer Res Commun
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive forms of pancreatic cancer, is associated with poor survival outcomes and currently ranks as the third leading cause of cancer-related death in the United States.
Khan K, Shameem M, Sigafoos AN, Kiey L, Hagen CE, Ramakrishnan G, Morse L, Fernandez-Zapico ME, Battaglino RA.   +8 more
europepmc   +2 more sources

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease. [PDF]

Oxid Med Cell Longev, 2022
Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, which is related to brain iron metabolism disorders. Ferroptosis is a newly discovered iron‐dependent programmed cell death mode, which has been considered an essential ...
Huang Z, Han J, Wu P, Wu C, Fan Y, Zhao L, Hao X, Chen D, Zhu M.   +8 more
europepmc   +2 more sources