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Sorting out the cellular functions of sorting nexins

Nature Reviews Molecular Cell Biology, 2002
Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting.
Carolyn A, Worby, Jack E, Dixon
exaly   +3 more sources

Retromer and sorting nexins in endosomal sorting

Biochemical Society Transactions, 2015
The evolutionarily conserved endosomal retromer complex rescues transmembrane proteins from the lysosomal degradative pathway and facilitates their recycling to other cellular compartments. Retromer functions in conjunction with numerous associated proteins, including select members of the sorting nexin (SNX) family.
Matthew, Gallon, Peter J, Cullen
openaire   +2 more sources

Tissue-specific regulatory role of Sorting Nexin 27 in the intestinal inflammation

Physiology, 2023
The sorting nexin (SNX) family involves in endocytosis and protein trafficking. SNX27 specifically binds and directs the sorting transmembrane proteins containing PDZ-binding motif and is critical in protein-protein interactions in various organs.
Jilei Zhang   +6 more
semanticscholar   +1 more source

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