Results 231 to 240 of about 545,864 (271)
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Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2.
Journal of Cell BiologyMutations or ablation of Snx10 are associated with neurodegeneration, blindness, and osteopetrosis. The similarities between osteoclasts and macrophages prompted us to analyze the role of Snx10 in phagocytosis.
J. Wu +8 more
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Cancer Research, 2022
Overexpression and/or overactivation of the Epidermal Growth Factor Receptor (EGFR) is oncogenic in several tumor types yet targeting the kinase domain of wildtype EGFR has had limited success.
Ben Atwell
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Overexpression and/or overactivation of the Epidermal Growth Factor Receptor (EGFR) is oncogenic in several tumor types yet targeting the kinase domain of wildtype EGFR has had limited success.
Ben Atwell
semanticscholar +1 more source
Sorting nexin 8 regulates endosome-to-Golgi transport
Biochemical and Biophysical Research Communications, 2009Sorting nexin 8 (SNX8) belongs to the sorting nexin protein family, whose members are involved in endocytosis and endosomal sorting and signaling. The function of SNX8 has so far been unknown. Here, we have investigated the role of SNX8 in intracellular transport of the bacterial toxin Shiga toxin (Stx) and the plant toxin ricin.
Anne Berit, Dyve +3 more
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Retromer and sorting nexins in development
Frontiers in Bioscience, 2007Trafficking and signaling processes involve common molecular components. The machinery that controls intracellular trafficking is vital in ensuring that signaling mechanisms take place correctly. An illustrative example of this relationship is the sustained signaling of endocytosed membrane receptors, such as receptor Tyr kinases and G-protein coupled ...
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Characterization of two sorting nexins : sorting nexin-11 and sorting nexin-30
2014The intracellular milieu is housed by countless numbers of intracellular molecules travelling by diffusion or along transient paths, which are regulated by specific trafficking proteins. Among these traffic regulators are the sorting nexins that determine the fate of internalized proteins by directing toward a defined path, which can lead to either ...
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Endosomal sorting and signalling: an emerging role for sorting nexins
Nature Reviews Molecular Cell Biology, 2008The endocytic network comprises a series of interconnected tubulo-vesicular membranous compartments that together regulate various sorting and signalling events. Although it is clear that defects in endocytic function underlie a variety of human diseases, our understanding of the molecular entities that regulate these sorting and signalling events ...
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Emerging Role of Sorting Nexin 17 in Human Health and Disease.
Current protein and peptide scienceThe distortion of the cellular membrane transport pathway has a profound impact on cell dynamics and can drive serious physiological consequences during the process of cell sorting.
Juan Chen +3 more
semanticscholar +1 more source
Association of Mouse Sorting Nexin 1 with Early Endosomes
Journal of Biochemistry, 2001Sorting nexin 1 (SNX1) is a protein that binds to the cytoplasmic domain of plasma membrane receptors. We found that mouse sorting nexin 1 (SNX1) (521 amino acid residues) could partially rescue a yeast vam3 mutant defective in docking/fusion of vacuolar membranes.
N, Nakamura +4 more
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Applied Immunohistochemistry & Molecular Morphology, 2014
Sorting nexins (SNXs) are a large, diverse group of cytoplasmic and membrane-associated proteins that function in a variety of cellular processes, including endocytosis, protein trafficking, and the retrieval of transmembrane proteins. In this study, we demonstrated that SNX2 is expressed in columnar and active thyroid follicular cells but not in ...
Maki, Kanzawa +5 more
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Sorting nexins (SNXs) are a large, diverse group of cytoplasmic and membrane-associated proteins that function in a variety of cellular processes, including endocytosis, protein trafficking, and the retrieval of transmembrane proteins. In this study, we demonstrated that SNX2 is expressed in columnar and active thyroid follicular cells but not in ...
Maki, Kanzawa +5 more
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The research status of the Sorting Nexins Family
Chinese Science Bulletin, 2014Sorting nexins (SNXs) is a general term for a large family of proteins containing a phox-homology (PX) domain. This family consists of 33 members in the mammalian proteome, whose PX domain efficiently binds phosphatidylinositol-3-phosphate, and is therefore recruited by early endosomal membranes.
YiHan CHEN, XiuE MA, YingYu CUI
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