The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes. [PDF]
Biochem JA dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes.
Jäverfelt S +4 more
europepmc +2 more sources
Macrophage Deficiency of Sorting Nexin 25 Suppress Plaque Formation in Atherosclerotic Lesions in Mice. [PDF]
Acta Histochem CytochemSNX25 is a member of the sorting nexin (SNX) superfamily, which plays crucial roles in membrane trafficking, cell signaling, and organelle dynamics. Our research has focused extensively on SNX25, demonstrating that SNX25-positive macrophages participate ...
Isonishi A +5 more
europepmc +2 more sources
An RGS-containing sorting nexin controls Drosophila lifespan. [PDF]
PLoS ONE, 2008 The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we ...
Jae Myoung Suh +5 more
doaj +4 more sources
Characterization of the First Secreted Sorting Nexin Identified in the Leishmania Protists. [PDF]
Int J Mol SciProteins of the sorting nexin (SNX) family present a modular structural architecture with a phox homology (PX) phosphoinositide (PI)-binding domain and additional PX structural domains, conferring to them a wide variety of vital eukaryotic cell’s ...
Tziouvara O +6 more
europepmc +2 more sources
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions. [PDF]
Immun AgeingBackground Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive deficits due to impairment of AMPA ...
Rodriguez-Rodriguez C +4 more
europepmc +2 more sources
Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2 [PDF]
eLife, 2021 The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors.
Kirsty J McMillan +12 more
doaj +2 more sources
A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting Nexin Complexes Involved in Autophagy. [PDF]
Biochemistry, 2023 The sorting nexin (SNX) proteins, Atg20 and Atg24, are involved in nonselective autophagy, are necessary for efficient selective autophagy, and are required for the cytoplasm-to-vacuole transport pathway.
Reinhart EF +4 more
europepmc +2 more sources
Effects of Genetic Variation of the Sorting Nexin 29 (SNX29) Gene on Growth Traits of Xiangdong Black Goat. [PDF]
Animals (Basel), 2022 Simple Summary With the development of goat industry, the improvement of goat production performance has become the primary task of goat industry.
Chen Y +9 more
europepmc +2 more sources
Association analysis of the sorting nexin 29 (SNX29) gene copy number variations with growth traits in Diannan small-ear (DSE) pigs. [PDF]
Anim BiotechnolSNX29 is a potential functional gene associated with meat production traits. Previous studies have shown that SNX29 copy number variation (CNV) could be implicated with phenotype in goats.
Yang L +8 more
europepmc +2 more sources
Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis [PDF]
Clinical Cancer Research, 2006 PURPOSE: Colon cancer is one of the most common human malignancies, yet studies have only begun to identify the multiple mechanisms that underlie the development of this tumor.
Bianchini, Michele +10 more
core +4 more sources