Results 51 to 60 of about 545,864 (271)

Solution structure of human sorting nexin 22 [PDF]

Protein Science, 2007
AbstractThe sorting nexins (SNXs) constitute a large group of PX domain‐containing proteins that play critical roles in protein trafficking. We report here the solution structure of human sorting nexin 22 (SNX22). Although SNX22 has <30% sequence identity with any PX domain protein of known structure, it was found to contain the α/β fold and compact
Jikui, Song, Kate Qin, Zhao, Carrie L Loushin, Newman, Dmitriy A, Vinarov, John L, Markley   +4 more
openaire   +2 more sources

Sorting Nexins – Unifying Trends and New Perspectives [PDF]

Traffic, 2004
The sorting nexins (SNXs) are a family of PX domain‐containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro‐degradative sorting, internalization, endosomal recycling, or simply in endosomal sorting.
Carlton, JG, Bujny, M, Rutherford, A, Cullen, P   +3 more
openaire   +3 more sources

SLIC‐1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL‐1 [PDF]

European Journal of Immunology, 2008
AbstractP‐Selectin glycoprotein ligand‐1 (PSGL‐1) is a mucin‐like glycoprotein expressed on the surface of leukocytes that serves as the major ligand for the selectin family of adhesion molecules and functions in leukocyte tethering and rolling on activated endothelium and platelets.
Ulrich Y, Schaff, Heather H, Shih, Meike, Lorenz, Dianne, Sako, Ron, Kriz, Kim, Milarski, Brian, Bates, Boris, Tchernychev, Gray D, Shaw, Scott I, Simon   +9 more
openaire   +2 more sources

SNX16 activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of eEF1A2 in colorectal cancer development

Molecular Oncology, 2020
Sorting nexin 16 (SNX16), a member of the sorting nexin family, has been implicated in tumor development. However, the function of SNX16 has not yet been investigated in colorectal cancer (CRC).
Zhiyong Shen, Yongsheng Li, Yuan Fang, Mingdao Lin, Xiaochuang Feng, Zhenkang Li, Yizhi Zhan, Yuechen Liu, Tingyu Mou, Xiaoliang Lan, Yanan Wang, Guoxin Li, Jiping Wang, Haijun Deng   +13 more
doaj   +1 more source

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts [PDF]

, 2017
Acknowledgements We sincerely thank the patients and family members who participated in this study. We would also like to thank Stefan Esher, Umeå University, for help with genealogy, and Anna Westerlund for excellent technical assistance.
Ameur, Adam, Coxon, Fraser P., Dahl, Niklas, Hallmans, Göran, Helfrich, Miep H., Henning, Petra, Kellgren, Therese G., Klar, Joakim, Lerner, Ulf H., Lönnerholm, Torsten, McDermott, Emma, Rydén, Patrik, Sandström, Per-Erik, Stattin, Eva-Lena, Stecksen-Blicks, Christina, Wikström, Johan   +15 more
core   +1 more source

Correction: Sorting out the cellular functions of sorting nexins [PDF]

Nature Reviews Molecular Cell Biology, 2003
Nature Rev. Mol. Cell Biol. 3, 919–931 (2002) The authors would like to apologize for the following omissions: The following reference should have been included in the reference list: Ref. 92 Reference 92 should have been cited on page 926, right column, 2nd line, at the end of the sentence: 'Finally, downregulation of G-protein-coupled protease ...
Carolyn A. Worby, Jack E. Dixon
openaire   +1 more source

Self-assembly and binding of a sorting nexin to sorting endosomes [PDF]

Journal of Cell Science, 2001
ABSTRACT The fate of endocytosed membrane proteins and luminal contents is determined by a materials processing system in sorting endosomes. Endosomal retention is a mechanism that traps specific proteins within this compartment, and thereby prevents their recycling.
R C, Kurten, A D, Eddington, P, Chowdhury, R D, Smith, A D, Davidson, B B, Shank   +5 more
openaire   +2 more sources

Sorting Nexin 10 Induces Giant Vacuoles in Mammalian Cells [PDF]

Journal of Biological Chemistry, 2006
Eukaryotic cells maintain a sophisticated network of intracellular membranous system to ensure the proper distribution and compartmentalization of cellular proteins critical for diverse functions such as cell division or cell-cell communication. Yet, little is known about the mechanism that regulates the homeostasis of this system.
Baoming Qin, Miao He, Xiao Chen, Duanqing Pei   +3 more
openalex   +4 more sources

HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1 [PDF]

, 2019
An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa.
Al-Saleem, Jacob, Dirksen, Wessel P, Green, Patrick L, Kvaratskhelia, Mamuka, Martinez, Michael P, Ratner, Lee, Shkriabai, Nikoloz   +6 more
core   +3 more sources

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
core   +1 more source