Results 61 to 70 of about 545,864 (271)

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]

, 2008
Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric, Ganley, Ian G., Pfeffer, Suzanne R.   +2 more
core   +4 more sources

Sorting nexins: role in the regulation of blood pressure [PDF]

The FEBS Journal, 2021
Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure via several mechanisms.
Juan Huang, Andrew C. Tiu, Pedro A. Jose, Jian Yang   +3 more
openaire   +2 more sources

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller, AD Ellington, AI Nesvizhskii, Alana Sterkel, Alex Stewart, Alexey Wolfson, Allison Weiss, Andrew B. Dalby, AS Levey, AS Levey, Ashley Bock, Ashley Forbes, AW Bell, B Schweitzer, BE Eaton, Bharat Gawande, Brian Hicke, Bridget Lollo, Britta Singer, Bruce E. Eaton, C Borrebaeck, C Tuerk, Cate Fowler, Chi Zhang, Christopher Bock, D Schneider, D Venturoli, D Zichi, D Zichi, Dan Nieuwlandt, Daniel I. Resnicow, Daniel Levine, Daniel Schneider, Deborah Ayers, Dennis Halladay, Dom Zichi, Dylan Flather, Edward N. Brody, EN Brody, ES Gragoudas, Evaldas Katilius, Fabrizio Gelain, Glenn Sanders, Gregory Husar, HK Binz, IC van Riemsdijk-van Overbeeke, J Ninio, J Ruckman, J Silberring, JD Vaught, JD Vaught, Jeff Carter, Jeffrey J. Walker, Jennifer Bertino, Jim Heil, JJ Hopfield, Joe Heilig, John Rohloff, Jonathan D. Vaught, K Chaudhary, L Gold, L Liotta, LA Gugliotti, LA Stevens, Larry Gold, Luke Kroiss, M Famulok, M Pascual, Magda Gunn, Malti Nikrad, Martin Stanton, Matt Otis, Meredith Goss, Michele Nelson, Mike Mehan, Mike Vrkljan, Mike Watrobka, Nancy Kim, Nebojsa Janjic, Ngan Le, P Mitchell, R Aebersold, R Craig, R Vanholder, Rachel M. Ostroff, RD Jenison, RF Service, RM Ostroff, Robert Mehler, S Fredriksson, S Pan, SA Doggrell, Sally K. Nelson, Sarah Sattin, Shashi Gupta, Sheela Waugh, Sheri K. Wilcox, Stephan Kraemer, Steve Pietrasiewicz, Steven K. Wolk, Susan Jennings, Suzanne Stratford, SV Giannelli, T Dewey, TA Addona, Tad H. Koch, Thale Jarvis, Thomas Parker, Tim Fitzwater, TL Nickolas, TM Tarasow, Tracy R. Keeney, Trudi Foreman, Urs Ochsner, Wes Lindsey, Wes Mayfield   +115 more
core   +10 more sources

Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats

Tumor Biology, 2017
As of 2012, liver cancer was the second leading cause of death worldwide, and hepatocellular carcinoma is the most common primary cancer of the liver.
Nancy Cervantes-Anaya, Alberto Ponciano-Gómez, Guadalupe Soledad López-Álvarez, Christian Gonzalez-Reyes, Sergio Hernández-Garcia, María Asunción Cabañas-Cortes, José Efraín Garrido-Guerrero, Saúl Villa-Treviño   +7 more
doaj   +1 more source

The role of motor proteins in endosomal sorting [PDF]

, 2011
Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
core   +2 more sources

Vps501 links sorting nexins to TORC1 regulation in budding yeast

Autophagy Reports, 2022
The lysosome in animal cells or the vacuole in plant and yeast cells serve as storage and/or recycling depots and their delimiting membranes host signaling events critical for starvation-induced cellular self-eating or macroautophagy/autophagy ...
Jacob H. Brock, Muhammad A. Rahman, Richard J. Chi   +2 more
doaj   +1 more source

Structural Predictions of the SNX-RGS Proteins Suggest They Belong to a New Class of Lipid Transfer Proteins

Frontiers in Cell and Developmental Biology, 2022
Recent advances in protein structure prediction using machine learning such as AlphaFold2 and RosettaFold presage a revolution in structural biology.
Blessy Paul, Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne, Brett M. Collins   +6 more
doaj   +1 more source

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways [PDF]

, 2016
A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common.
Banks, Lawrence, Ganti, Ketaki, John, Doorbar, Kranjec, Christian, Lizano, Marcela, Manzo-Merino, Joaquin, Massimi, Paola, Pim, David, Playford, Martin P, Roberts, Sally, Tomaić, Vjekoslav   +10 more
core   +2 more sources

The sorting nexin requirement of the Vps68 recycling signal is context dependent

bioRxiv, 2023
Here we analyzed the recycling of the Vps55/Vps68 complex in the yeast endocytic pathway. Deletion of VPS55 and VPS68 caused the same moderate stabilization of the endocytic cargo protein Ste6.
Ralf Kölling
semanticscholar   +1 more source

Determinants of the Endosomal Localization of Sorting Nexin 1 [PDF]

Molecular Biology of the Cell, 2005
The sorting nexin (SNX) family of proteins is characterized by sequence-related phox homology (PX) domains. A minority of PX domains bind with high affinity to phosphatidylinositol 3-phosphate [PI(3)P], whereas the majority of PX domains exhibit low affinity that is insufficient to target them to vesicles.
Zhong, Qi, Watson, Martin J., Lazar, Cheri S., Hounslow, Andrea M., Waltho, Jonathan P., Gill, Gordon N.   +5 more
openaire   +3 more sources