Results 71 to 80 of about 545,864 (271)
Sorting Out Sorting Nexins Functions in the Nervous System in Health and Disease [PDF]
Molecular Neurobiology, 2021 AbstractEndocytosis is a fundamental process that controls protein/lipid composition of the plasma membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient uptake. Endocytosis is essential for the cell to adapt to its surrounding environment, and a tight regulation of the endocytic mechanisms is required to maintain ...
Neide Vieira +3 more
openaire +2 more sources
Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein [PDF]
, 2015 Although endolysosomal trafficking is well defined, how it is regulated and coordinates with cellular metabolism is unclear. To identify genes governing endolysosomal dynamics, we conducted a global fluorescence-based screen to reveal endomembrane ...
Balogi, Z +5 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Autosomal dominant polycystic kidney disease (ADPKD) is a complex process, involving the alteration of multiple genes and signaling pathways, and the pathogenesis of ADPKD remains largely unknown.
Ai-Wen Shen +8 more
doaj +1 more source
Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages [PDF]
, 2016 Cadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by ...
Ji, CL +6 more
core +1 more source
Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains [PDF]
, 2007 BACKGROUND: A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP and iNP rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred
Benjamini Y +9 more
core +1 more source
Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes
Haematologica, 2022 Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets.
Joanne Lacey +9 more
semanticscholar +1 more source
Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour [PDF]
Genes, Brain and Behavior, 2019 AbstractTemperature sensing is an important adaptive mechanism for warm‐blooded animals such as humans. ThermoTRP ion channels are activated by distinct but overlapping physiological temperatures. Our previous research demonstrated that sorting nexin 11 (SNX11) regulates lysosomal degradation of plasma membrane TRPV3, one of ThermoTRP ion channel ...
Hualin Huang +12 more
openalex +3 more sources
Nature Communications, 2018 Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a ...
Marc Lenoir +6 more
doaj +1 more source
Sorting nexin-1 is a candidate tumor suppressor and potential prognostic marker in gastric cancer [PDF]
PeerJ, 2018 Sorting nexin-1 (SNX1) is an important functional protein in cell endocytosis, efflux, protein sorting, cell signal transduction, etc; however, the expression, the role and clinical relevance of SNX1 have not been investigated in gastric cancer (GC).
Xiao-Yong Zhan +4 more
doaj +2 more sources
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
doaj +1 more source