Results 81 to 90 of about 545,864 (271)
Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]
, 2013 Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A. +6 more
core +2 more sources
Regulation of the endosomal SNX27-retromer by OTULIN
Nature Communications, 2019 OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 ...
Aurelia Stangl +12 more
doaj +1 more source
The emerging role of sorting nexins in cardiovascular diseases [PDF]
Clinical Science, 2019 Abstract The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling.
Jian Yang +4 more
openaire +2 more sources
Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity
Cell Reports, 2014 Patients with Down syndrome (DS) invariably develop Alzheimer’s disease (AD) pathology in their 40s. We have recently found that overexpression of a chromosome 21-encoded microRNA-155 results in decreased levels of the membrane trafficking component ...
Xin Wang +8 more
doaj +1 more source
Distinct cellular expression pattern of annexins in Hydra vulgaris. [PDF]
, 1992 The annexins are a structurally related family of Ca2+ and phospholipid binding proteins whose function has not been clearly defined. Further investigations of annexin function may be enhanced by studying simpler organisms that express fewer annexin gene
Bode, HR, Haigler, HT, Schlaepfer, DD
core +2 more sources
Peter Cullen: Nexins have it sorted [PDF]
Journal of Cell Biology, 2014 Cullen studies protein sorting in the endosomal network.
openaire +1 more source
Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia [PDF]
, 2016 Schizophrenia is a complex polygenic disorder of unknown etiology. Over 3,000 candidate genes associated with schizophrenia have been reported, most of which being mentioned only once.
Babić Leko, M +9 more
core +2 more sources
Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]
, 2012 The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core +2 more sources
EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin 9 [PDF]
Journal of Bacteriology, 2006 ABSTRACT EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via
Marchès, Oliver +13 more
openaire +3 more sources
bioRxiv, 2021 The sorting nexin SNX17 controls endosome-to-cell surface recycling of diverse transmembrane cargo proteins including integrins, the amyloid precursor protein and lipoprotein receptors.
Michael D Healy +10 more
semanticscholar +1 more source