Results 91 to 100 of about 23,758 (203)
Advanced Science, Volume 13, Issue 4, 19 January 2026.The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu +20 more
wiley +1 more source
Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression.
PLoS ONE, 2011 The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass.
Damian C Genetos +2 more
doaj +1 more source
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
core +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang +8 more
wiley +1 more source
Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions
MedComm, Volume 7, Issue 1, January 2026.The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin +3 more
wiley +1 more source
Exact relaxation for polynomial optimization on semi-algebraic sets [PDF]
, 2013 In this paper, we study the problem of computing by relaxation hierarchies the infimum of a real polynomial function f on a closed basic semialgebraic set and the points where this infimum is reached, if they exist.
Bucero, Marta Abril, Mourrain, Bernard
core +4 more sources
Zhongguo shiyan zhenduanxue, 2021 硬骨素(SOST)是一种主要由骨细胞分泌的蛋白质,其主要功能是抑制成骨细胞矿化,进而抑制骨形成[1]。维生素D缺乏性佝偻病患儿早期便会出现骨矿化不足。本研究拟通过分析患维生素D缺乏性佝偻病的婴幼儿血清SOST的水平变化,探讨SOST在佝偻病诊断中的意义。
李嘉, 刘晓燕, 彭慧云, 陈耀武
doaj
Dois pontos sobre uma linha curva [PDF]
, 2002 Short piano piece composed between May and August of 2002 in São Paulo ...
Ruviaro, Bruno
core +1 more source
Coherence-Based Performance Guarantees of Orthogonal Matching Pursuit
, 2012 In this paper, we present coherence-based performance guarantees of Orthogonal Matching Pursuit (OMP) for both support recovery and signal reconstruction of sparse signals when the measurements are corrupted by noise.
Calderbank, Robert, Chi, Yuejie
core +1 more source
Detection of early osteogenic commitment in primary cells using Raman spectroscopy [PDF]
, 2017 Major challenges in the development of novel implant surfaces for artificial joints include osteoblast heterogeneity and the lack of a simple and sensitive in vitro assay to measure early osteogenic responses.
Clarkin, C E +4 more
core +1 more source